Soliton-like regimes and excitation pulse reflection (echo) in homogeneous cardiac purkinje fibers: results of numerical simulations

On the basis of numerical simulations of the partial McAllister-Noble-Tsien equations quantitatively describing the dynamics of electrical processes in conductive cardiac Purkinje fibers we reveal unusual - soliton-like - regimes of interaction of nonlinear excitation pulses governing the heart cont...

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Bibliographic Details
Published in:Journal of biological physics 1999-06, Vol.25 (2-3), p.149-164
Main Authors: Aslanidi, O V, Mornev, O A
Format: Article
Language:English
Subjects:
Biophysics
Cardiology
Heart
Simulation
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Summary:On the basis of numerical simulations of the partial McAllister-Noble-Tsien equations quantitatively describing the dynamics of electrical processes in conductive cardiac Purkinje fibers we reveal unusual - soliton-like - regimes of interaction of nonlinear excitation pulses governing the heart contraction rhythm: reflection of colliding pulses instead of their annihilation. The phenomenological mechanism of the reflection effects is that in a narrow (but finite) range of the system parameters the traveling pulse presents a doublet consisting of a high-amplitude leader followed by a low-amplitude subthreshold wave. Upon collisions of pulses the leaders are annihilated, but subthreshold waves summarize becoming superthreshold and initiating two novel echo-pulses traveling in opposite directions. The phenomenon revealed presents an analogy to the effect of reflection of colliding nerve pulses, predicted recently, and can be of use in getting insight into the mechanisms of heart rhythm disturbances.
ISSN:0092-0606
1573-0689
DOI:10.1023/A:1005119218136