Polyamines are Inhibitors of Gastric Acid Secretion

The naturally occurring organic polycations such as spermine and spermidine inhibit histamine-stimulated gastric acid secretion by bullfrog gastric mucosa in vitro; spermine is much more potent than spermidine. Unlike the H2receptor antagonists, the polyamines are completely ineffective from the nut...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1982-03, Vol.79 (5), p.1448-1452
Main Authors: Ray, Tushar K., Nandi, Jyotirmoy, Pidhorodeckyj, Nykolai, Meng-Ai, Zhou
Format: Article
Language:English
Subjects:
acids
Acridines
Adenosine triphosphatases
Animals
Biological Transport - drug effects
Cell-Free System
Gastric juice
Gastric Juice - metabolism
Gastric mucosa
Gastric Mucosa - metabolism
Hydrogen-Ion Concentration
Microsomes
Microsomes - metabolism
Mucosa
Nutrient solutions
pigs
Polyamines
Polyamines - pharmacology
Potassium - metabolism
Secretion
Sperm transport
Spermidine - pharmacology
Spermine - pharmacology
stomach
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Summary:The naturally occurring organic polycations such as spermine and spermidine inhibit histamine-stimulated gastric acid secretion by bullfrog gastric mucosa in vitro; spermine is much more potent than spermidine. Unlike the H2receptor antagonists, the polyamines are completely ineffective from the nutrient side and are effective only from the secretory side of the chambered mucosa. The polyamine effects could be reversed by increasing K+concentration in the secretory solution. Studies with isolated gastric microsomal vesicles demonstrate that the polyamines do not inhibit the gastric H+,K+-ATPase but greatly decrease the ATPase-mediated uptake of H+under appropriate conditions. For the latter effects the presence of polyamine within the vesicle interior was found to be essential. Our data strongly suggest an uncoupling of the gastric H+,K+-ATPase system by the polyamines. The therapeutic potential of these and similar compounds in the treatment of hyperacidity and peptic ulcer is discussed.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.79.5.1448