The complotype: dictating risk for inflammation and infection

Complement is a key component of immune defence against infection; it potently drives inflammation at sites of pathology and is essential for killing of pathogens. Genetic linkage of common complement polymorphisms to disease has advanced the concept that subtle changes in complement activity signif...

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Bibliographic Details
Published in:Trends in immunology 2012-10, Vol.33 (10), p.513-521
Main Authors: Harris, Claire L, Heurich, Meike, Cordoba, Santiago Rodriguez de, Morgan, B. Paul
Format: Article
Language:English
Subjects:
Allergy and Immunology
alternative pathway
Animals
Binding sites
complement
complotype
Disease
Genes
Genotype
Haplotypes
Humans
Immune system
Infection - genetics
Infection - immunology
Infections
infectious diseases
inflammation
Inflammation - genetics
Inflammation - immunology
Macular degeneration
Mortality
pathogens
Plasma
Polymorphism, Genetic
prediction
Proteins
Review
risk
Risk Factors
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Summary:Complement is a key component of immune defence against infection; it potently drives inflammation at sites of pathology and is essential for killing of pathogens. Genetic linkage of common complement polymorphisms to disease has advanced the concept that subtle changes in complement activity significantly affect disease risk. Functional analyses of disease-linked polymorphic variants demonstrate that, although individual polymorphisms cause only small changes in activity, when combined, the aggregate effects are large. The inherited set of common variants, the complotype, thus has a major impact on susceptibility to inflammatory and infectious diseases. Assessing the complotype of an individual will aid prediction of disease risk and inform intervention to reduce or eliminate risk.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2012.06.001