PABPN1 shuts down alternative poly（A） sites

Although overlooked for many years, alternative cleavage and polyadenylation （APA） is now emerging as a major mechanism ofgene regulation. A recent study identifies poly（A）- binding protein nuclear 1 （PABPN1）, a general factor of polyadenylation, as a suppressor of alternative poly（A） sites....

Full description

Saved in:
Bibliographic Details
Published in:Cell research 2012-10, Vol.22 (10), p.1419-1421
Main Author: Simonelig, Martine
Format: Article
Language:English
Subjects:
3' Untranslated Regions
631/208/200
631/337/1645
631/45/612/1230
Animals
APA
Biomedical and Life Sciences
Cell Biology
Cell Line
Drosophila
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Genetics
Humans
Life Sciences
Mutation
Poly A - metabolism
Poly(A)-Binding Protein I - genetics
Poly(A)-Binding Protein I - metabolism
Research Highlight
RNA, Messenger - metabolism
Schizosaccharomyces - metabolism
Schizosaccharomyces pombe Proteins - genetics
Schizosaccharomyces pombe Proteins - metabolism
关闭
聚腺苷
蛋白核
酸化
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although overlooked for many years, alternative cleavage and polyadenylation （APA） is now emerging as a major mechanism ofgene regulation. A recent study identifies poly（A）- binding protein nuclear 1 （PABPN1）, a general factor of polyadenylation, as a suppressor of alternative poly（A） sites.
ISSN:1001-0602
1748-7838
DOI:10.1038/cr.2012.86