Binding of a tritiated inverse agonist to cannabinoid CB1 receptors is increased in patients with schizophrenia

Abstract This study sought to determine whether cannabinoid-1 (CB1 ) receptor binding was altered in the postmortem dorsolateral prefrontal cortex (DLPFC) of individuals with schizophrenia (schizophrenia; n = 47) compared to controls ( n = 43). The CB1 receptor inverse agonist radioligand [3 H]MePPE...

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Bibliographic Details
Published in:Schizophrenia research 2012-11, Vol.141 (2), p.185-188
Main Authors: Jenko, Kimberly J, Hirvonen, Jussi, Henter, Ioline D, Anderson, Kacey B, Zoghbi, Sami S, Hyde, Thomas M, Deep-Soboslay, Amy, Innis, Robert B, Kleinman, Joel E
Format: Article
Language:English
Subjects:
[3H]MePPEP
Adult
Adult and adolescent clinical studies
Aged
Biological and medical sciences
Cannabinoid
CB1
Cohort Studies
Dorsolateral prefrontal cortex
Female
Fluorine Radioisotopes - pharmacokinetics
Humans
Male
Medical sciences
Middle Aged
Polymorphism, Single Nucleotide - genetics
Positron-Emission Tomography
Prefrontal Cortex - diagnostic imaging
Prefrontal Cortex - drug effects
Protein Binding - drug effects
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Pyrrolidinones - pharmacokinetics
Receptor, Cannabinoid, CB1 - genetics
Receptor, Cannabinoid, CB1 - metabolism
Regression Analysis
Schizophrenia
Schizophrenia - diagnostic imaging
Schizophrenia - genetics
Schizophrenia - pathology
Tissue Distribution - drug effects
Tritium - pharmacokinetics
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Summary:Abstract This study sought to determine whether cannabinoid-1 (CB1 ) receptor binding was altered in the postmortem dorsolateral prefrontal cortex (DLPFC) of individuals with schizophrenia (schizophrenia; n = 47) compared to controls ( n = 43). The CB1 receptor inverse agonist radioligand [3 H]MePPEP was used to measure specific binding to CB1 receptors. The specific binding of [3 H]MePPEP to CB1 receptors was 20% higher in patients with schizophrenia than in controls. Power analyses suggested that 53 subjects per group would be needed to detect a similar difference in vivo with positron emission tomography (PET) and the structurally related inverse agonist radioligand [18 F]FMPEP- d2 (80% statistical power, p < 0.05).
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2012.07.021