In vivo comparison of arterial lumen dimensions assessed by co-registered three-dimensional (3D) quantitative coronary angiography, intravascular ultrasound and optical coherence tomography

• Published in: International Journal of Cardiovascular Imaging 2012-08, Vol.28 (6), p.1315-1327
• Main Authors: Tu, Shengxian, Xu, Liang, Ligthart, Jurgen, Xu, Bo, Witberg, Karen, Sun, Zhongwei, Koning, Gerhard, Reiber, Johan H. C., Regar, Evelyn
• Format: Article
• Language: English
• Subjects: Adult; Aged; Cardiac Imaging; Cardiology; Coronary Angiography - methods; Coronary Artery Disease - diagnosis; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - pathology; Coronary Vessels - diagnostic imaging; Coronary Vessels - pathology; Female; Humans; Imaging; Imaging, Three-Dimensional; Linear Models; Male; Medicine; Medicine & Public Health; Middle Aged; Multivariate Analysis; Original Paper; Predictive Value of Tests; Radiology; Retrospective Studies; Tomography, Optical Coherence; Ultrasonography, Interventional
• ISSN: 1569-5794; 1573-0743; 1875-8312
• DOI: 10.1007/s10554-012-0016-6

This study sought to compare lumen dimensions as assessed by 3D quantitative coronary angiography (QCA) and by intravascular ultrasound (IVUS) or optical coherence tomography (OCT), and to assess the association of the discrepancy with vessel curvature. Coronary lumen dimensions often show discrepancies when assessed by X-ray angiography and by IVUS or OCT. One source of error concerns a possible mismatch in the selection of corresponding regions for the comparison. Therefore, we developed a novel, real-time co-registration approach to guarantee the point-to-point correspondence between the X-ray, IVUS and OCT images. A total of 74 patients with indication for cardiac catheterization were retrospectively included. Lumen morphometry was performed by 3D QCA and IVUS or OCT. For quantitative analysis, a novel, dedicated approach for co-registration and lumen detection was employed allowing for assessment of lumen size at multiple positions along the vessel. Vessel curvature was automatically calculated from the 3D arterial vessel centerline. Comparison of 3D QCA and IVUS was performed in 519 distinct positions in 40 vessels. Correlations were r  = 0.761, r  = 0.790, and r  = 0.799 for short diameter (SD), long diameter (LD), and area, respectively. Lumen sizes were larger by IVUS ( P