Status and access to the Collaborative Cross population

• Published in: Mammalian genome 2012-10, Vol.23 (9-10), p.706-712
• Main Authors: Welsh, Catherine E, Miller, Darla R, Manly, Kenneth F, Wang, Jeremy, McMillan, Leonard, Morahan, Grant, Mott, Richard, Iraqi, Fuad A, Threadgill, David W, de Villena, Fernando Pardo-Manuel
• Format: Article
• Language: English
• Subjects: Animal Genetics and Genomics; Animals; Biomedical and Life Sciences; breeding sites; Cell Biology; Cooperative Behavior; Genome; genotype; Human Genetics; inbred lines; inbreeding; Indexing in process; Internet; Life Sciences; Male; Mice; Mice, Inbred Strains - genetics
• ISSN: 0938-8990; 1432-1777
• DOI: 10.1007/s00335-012-9410-6

The Collaborative Cross (CC) is a panel of recombinant inbred lines derived from eight genetically diverse laboratory inbred strains. Recently, the genetic architecture of the CC population was reported based on the genotype of a single male per line, and other publications reported incompletely inbred CC mice that have been used to map a variety of traits. The three breeding sites, in the US, Israel, and Australia, are actively collaborating to accelerate the inbreeding process through marker-assisted inbreeding and to expedite community access of CC lines deemed to have reached defined thresholds of inbreeding. Plans are now being developed to provide access to this novel genetic reference population through distribution centers. Here we provide a description of the distribution efforts by the University of North Carolina Systems Genetics Core, Tel Aviv University, Israel and the University of Western Australia.