Bone Marrow Microenvironment in Multiple Myeloma Progression

Substantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bone marrow (BM) microenvironment. Indeed, the BM niche appears to play an important role in differentiation, migration, proliferation, survival, and drug resistance of the malignant pl...

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Bibliographic Details
Published in:BioMed research international 2012-01, Vol.2012 (2012), p.1-5
Main Authors: Ghobrial, I. M., Sacco, A., Leleu, X., Roccaro, A. M., Manier, S.
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Bone marrow
Bone Marrow - immunology
Cancer
Cell cycle
Cell differentiation
Cell growth
Chemokines
Cytokines
Cytokines - immunology
Development and progression
Extracellular matrix
Health aspects
Humans
Hypoxia
Models, Immunological
Multiple myeloma
Multiple Myeloma - immunology
Mutation
Physiological aspects
Plasma
Proteins
Review
Tumors
Vascular endothelial growth factor
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Summary:Substantial advances have been made in understanding the biology of multiple myeloma (MM) through the study of the bone marrow (BM) microenvironment. Indeed, the BM niche appears to play an important role in differentiation, migration, proliferation, survival, and drug resistance of the malignant plasma cells. The BM niche is composed of a cellular compartment (stromal cells, osteoblasts, osteoclasts, endothelial cells, and immune cells) and a noncellular compartment including the extracellular matrix (ECM) and the liquid milieu (cytokines, growth factors, and chemokines). In this paper we discuss how the interaction between the malignant plasma cell and the BM microenvironment allowed myeloma progression through cell homing and the new concept of premetastatic niche.
ISSN:1110-7243
2314-6133
1110-7251
2314-6141
DOI:10.1155/2012/157496