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Synthetic polymer coatings for long-term growth of human embryonic stem cells
We report a fully defined synthetic polymer coating, poly[2-(methacryloyloxy)ethyl dimethyl-(3-sulfopropyl)ammonium hydroxide] (PMEDSAH), which sustains long-term human embryonic stem (hES) cell growth in several different culture media, including commercially available defined media. The developmen...
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| Published in: | Nature biotechnology 2010-06, Vol.28 (6), p.581-583 |
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| Main Authors: | , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c755t-8866ba1a0004d31a0b6234e23855f8e640a93e2d3fc019763b3f8b9f8851dc553 |
| container_end_page | 583 |
| container_issue | 6 |
| container_start_page | 581 |
| container_title | Nature biotechnology |
| container_volume | 28 |
| creator | Lahann, Joerg Smith, Gary D Villa-Diaz, Luis G Nandivada, Himabindu Ding, Jun Nogueira-de-Souza, Naiara C Krebsbach, Paul H O'Shea, K Sue |
| description | We report a fully defined synthetic polymer coating, poly[2-(methacryloyloxy)ethyl dimethyl-(3-sulfopropyl)ammonium hydroxide] (PMEDSAH), which sustains long-term human embryonic stem (hES) cell growth in several different culture media, including commercially available defined media. The development of a standardized, controllable and sustainable culture matrix for hES cells is an essential step in elucidating mechanisms that control hES cell behavior and in optimizing conditions for biomedical applications of hES cells. |
| doi_str_mv | 10.1038/nbt.1631 |
| format | article |
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The development of a standardized, controllable and sustainable culture matrix for hES cells is an essential step in elucidating mechanisms that control hES cell behavior and in optimizing conditions for biomedical applications of hES cells.</description><identifier>ISSN: 1087-0156</identifier><identifier>EISSN: 1546-1696</identifier><identifier>DOI: 10.1038/nbt.1631</identifier><identifier>PMID: 20512122</identifier><identifier>CODEN: NABIF9</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/532/2117 ; 631/61/2320 ; 631/61/338/552 ; 631/80/641/83 ; Agriculture ; Ammonium ; Animals ; Bioinformatics ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedical Engineering/Biotechnology ; Biomedicine ; Biotechnology ; brief-communication ; Cell Culture Techniques - methods ; Cell Proliferation - drug effects ; Cells, Cultured ; Coated Materials, Biocompatible - pharmacology ; Culture media ; Culture Media - pharmacology ; Embryonic stem cells ; Embryonic Stem Cells - cytology ; Embryonic Stem Cells - drug effects ; Embryos ; Fibroblasts - cytology ; Fibroblasts - drug effects ; Fundamental and applied biological sciences. 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Economical aspects ; Life Sciences ; Mice ; Miscellaneous ; Physiological aspects ; Polymers ; Polymers - pharmacology ; Stem cells ; Time Factors</subject><ispartof>Nature biotechnology, 2010-06, Vol.28 (6), p.581-583</ispartof><rights>Springer Nature America, Inc. 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jun 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c755t-8866ba1a0004d31a0b6234e23855f8e640a93e2d3fc019763b3f8b9f8851dc553</citedby><cites>FETCH-LOGICAL-c755t-8866ba1a0004d31a0b6234e23855f8e640a93e2d3fc019763b3f8b9f8851dc553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,2727,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22896652$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20512122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lahann, Joerg</creatorcontrib><creatorcontrib>Smith, Gary D</creatorcontrib><creatorcontrib>Villa-Diaz, Luis G</creatorcontrib><creatorcontrib>Nandivada, Himabindu</creatorcontrib><creatorcontrib>Ding, Jun</creatorcontrib><creatorcontrib>Nogueira-de-Souza, Naiara C</creatorcontrib><creatorcontrib>Krebsbach, Paul H</creatorcontrib><creatorcontrib>O'Shea, K Sue</creatorcontrib><title>Synthetic polymer coatings for long-term growth of human embryonic stem cells</title><title>Nature biotechnology</title><addtitle>Nat Biotechnol</addtitle><addtitle>Nat Biotechnol</addtitle><description>We report a fully defined synthetic polymer coating, poly[2-(methacryloyloxy)ethyl dimethyl-(3-sulfopropyl)ammonium hydroxide] (PMEDSAH), which sustains long-term human embryonic stem (hES) cell growth in several different culture media, including commercially available defined media. 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The development of a standardized, controllable and sustainable culture matrix for hES cells is an essential step in elucidating mechanisms that control hES cell behavior and in optimizing conditions for biomedical applications of hES cells.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>20512122</pmid><doi>10.1038/nbt.1631</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/532/2117 631/61/2320 631/61/338/552 631/80/641/83 Agriculture Ammonium Animals Bioinformatics Biological and medical sciences Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology brief-communication Cell Culture Techniques - methods Cell Proliferation - drug effects Cells, Cultured Coated Materials, Biocompatible - pharmacology Culture media Culture Media - pharmacology Embryonic stem cells Embryonic Stem Cells - cytology Embryonic Stem Cells - drug effects Embryos Fibroblasts - cytology Fibroblasts - drug effects Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Life Sciences Mice Miscellaneous Physiological aspects Polymers Polymers - pharmacology Stem cells Time Factors |
| title | Synthetic polymer coatings for long-term growth of human embryonic stem cells |
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