Computed tomography coronary angiography accuracy in women and men at low to intermediate risk of coronary artery disease

• Published in: European radiology 2012-11, Vol.22 (11), p.2415-2423
• Main Authors: Dharampal, Anoeshka S., Papadopoulou, Stella L., Rossi, Alexia, Weustink, Annick C., Mollet, Nico R. A., Meijboom, W. Bob, Neefjes, Lisan A., Nieman, Koen, Boersma, Eric, de Feijter, Pim J., Krestin, Gabriel P.
• Format: Article
• Language: English
• Subjects: Accuracy; Adult; Aged; Cardiovascular disease; Computed Tomography; Contraindications; Coronary Angiography - methods; Coronary Artery Disease - diagnosis; Coronary Artery Disease - pathology; Coronary vessels; Diagnostic Radiology; Electrocardiography; Female; Humans; Image Processing, Computer-Assisted; Imaging; Internal Medicine; Interventional Radiology; Iodine; Male; Medical imaging; Medicine; Medicine & Public Health; Middle Aged; Neuroradiology; Nuclear polyhedrosis virus; Probability; Radiology; Reproducibility of Results; Retrospective Studies; Risk; Sensitivity and Specificity; Sex Factors; Tomography; Ultrasound; Vein & artery diseases; Women
• ISSN: 0938-7994; 1432-1084
• DOI: 10.1007/s00330-012-2503-5

Objectives To investigate the diagnostic accuracy of CT coronary angiography (CTCA) in women at low to intermediate pre-test probability of coronary artery disease (CAD) compared with men. Methods In this retrospective study we included symptomatic patients with low to intermediate risk who underwent both invasive coronary angiography and CTCA. Exclusion criteria were previous revascularisation or myocardial infarction. The pre-test probability of CAD was estimated using the Duke risk score. Thresholds of less than 30 % and 30–90 % were used for determining low and intermediate risk, respectively. The diagnostic accuracy of CTCA in detecting obstructive CAD (≥50 % lumen diameter narrowing) was calculated on patient level. P