Fulminant myocarditis owing to high-dose interleukin-2 therapy for metastatic melanoma

High-dose interleukin-2 (IL-2) therapy may cause acute myocarditis characterised by diffuse myocardial involvement and occasionally fulminant heart failure. Cardiac MRI (CMRI) provides a comprehensive assessment of myocardial function, inflammation and injury in a single examination and has shown va...

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Bibliographic Details
Published in:British journal of radiology 2011-05, Vol.84 (1001), p.e99-e102
Main Authors: Thavendiranathan, P, Verhaert, D, Kendra, K L, Raman, S V
Format: Article
Language:English
Subjects:
Acute Disease
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - adverse effects
Case Report
Gadolinium
Humans
Interleukin-2 - administration & dosage
Interleukin-2 - adverse effects
Magnetic Resonance Imaging - methods
Male
Melanoma - drug therapy
Melanoma - secondary
Middle Aged
Myocarditis - chemically induced
Myocarditis - diagnosis
Treatment Outcome
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Summary:High-dose interleukin-2 (IL-2) therapy may cause acute myocarditis characterised by diffuse myocardial involvement and occasionally fulminant heart failure. Cardiac MRI (CMRI) provides a comprehensive assessment of myocardial function, inflammation and injury in a single examination and has shown value in the diagnosis of myocarditis. We report a case of a 54-year-old male with metastatic melanoma who developed acute severe myocarditis with fulminant heart failure after high-dose IL-2 therapy. CMRI using a combination of T(2) weighted imaging and T(1) weighted late post-gadolinium enhancement techniques played a key role in establishing the diagnosis. To our knowledge we present the first case report of the combined use of T(1) and T(2) weighted CMRI techniques to diagnose IL-2 induced myocarditis.
ISSN:0007-1285
1748-880X
DOI:10.1259/bjr/13448473