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Differentiating osteoradionecrosis from nasopharyngeal carcinoma tumour recurrence using ⁹⁹Tcm-sestamibi SPECT/CT

Osteoradionecrosis (ORN) of the base of skull is a known complication of external beam radiotherapy in the treatment of nasopharyngeal carcinoma, and is widely believed to be sequelae of radiation-induced endarteritis, leading to cellular death and fibrosis. Differentiating ORN from tumour recurrenc...

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Published in:	British journal of radiology 2011-09, Vol.84 (1005), p.e172-e175
Main Authors:	Tan, A E H, Ng, D C E
Format:	Article
Language:	English
Subjects:	Aged Bone imaging Carcinoma, Squamous Cell - diagnostic imaging Carcinoma, Squamous Cell - radiotherapy Case Report Complications Computed tomography Diagnosis, Differential Endarteritis Fibrosis Fluorodeoxyglucose F18 Humans Male Nasopharyngeal carcinoma Nasopharyngeal Neoplasms - diagnostic imaging Nasopharyngeal Neoplasms - radiotherapy Neoplasm Recurrence, Local - diagnostic imaging Osteoradionecrosis Osteoradionecrosis - diagnostic imaging Osteoradionecrosis - pathology Radiopharmaceuticals Radiotherapy Scintigraphy Single photon emission computed tomography Skull Technetium Tc 99m Sestamibi Tomography, Emission-Computed, Single-Photon - methods Tomography, X-Ray Computed Treatment Outcome
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description	Osteoradionecrosis (ORN) of the base of skull is a known complication of external beam radiotherapy in the treatment of nasopharyngeal carcinoma, and is widely believed to be sequelae of radiation-induced endarteritis, leading to cellular death and fibrosis. Differentiating ORN from tumour recurrence is challenging and has direct clinical implications. We present a case where (99)Tc(m)-sestamibi SPECT/CT was used to differentiate ORN from tumour recurrence and in which prior imaging using bone scintigraphy and fluorodeoxyglucose PET/CT were equivocal.
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subjects	Aged Bone imaging Carcinoma, Squamous Cell - diagnostic imaging Carcinoma, Squamous Cell - radiotherapy Case Report Complications Computed tomography Diagnosis, Differential Endarteritis Fibrosis Fluorodeoxyglucose F18 Humans Male Nasopharyngeal carcinoma Nasopharyngeal Neoplasms - diagnostic imaging Nasopharyngeal Neoplasms - radiotherapy Neoplasm Recurrence, Local - diagnostic imaging Osteoradionecrosis Osteoradionecrosis - diagnostic imaging Osteoradionecrosis - pathology Radiopharmaceuticals Radiotherapy Scintigraphy Single photon emission computed tomography Skull Technetium Tc 99m Sestamibi Tomography, Emission-Computed, Single-Photon - methods Tomography, X-Ray Computed Treatment Outcome
title	Differentiating osteoradionecrosis from nasopharyngeal carcinoma tumour recurrence using ⁹⁹Tcm-sestamibi SPECT/CT
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