Effect of antenatal iodinated contrast agent on neonatal thyroid function

The aim of this study was to assess the effect on neonatal thyroid function of iodinated contrast media administered for CT pulmonary angiography (CTPA) in babies whose mothers were investigated for suspected pulmonary embolism during pregnancy. Retrospective review of 115 pregnant patients investig...

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Bibliographic Details
Published in:British journal of radiology 2012-07, Vol.85 (1015), p.e238-e242
Main Authors: Rajaram, S, Exley, C E, Fairlie, F, Matthews, S
Format: Article
Language:English
Subjects:
Adult
Angiography - adverse effects
Angiography - methods
Case-Control Studies
Contrast Media - adverse effects
Contrast Media - pharmacology
Female
Follow-Up Studies
Gestational Age
Humans
Infant, Newborn
Iodine Radioisotopes - adverse effects
Male
Neonatal Screening - methods
Pregnancy
Pregnancy Complications, Cardiovascular - diagnosis
Pregnancy Complications, Cardiovascular - diagnostic imaging
Prenatal Diagnosis - adverse effects
Prenatal Diagnosis - methods
Prenatal Exposure Delayed Effects - blood
Prenatal Exposure Delayed Effects - chemically induced
Pulmonary Embolism - diagnostic imaging
Reference Values
Retrospective Studies
Risk Assessment
Thyroid Function Tests
Thyroid Gland - drug effects
Tomography, X-Ray Computed - adverse effects
Tomography, X-Ray Computed - methods
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Summary:The aim of this study was to assess the effect on neonatal thyroid function of iodinated contrast media administered for CT pulmonary angiography (CTPA) in babies whose mothers were investigated for suspected pulmonary embolism during pregnancy. Retrospective review of 115 pregnant patients investigated for suspected pulmonary embolism. The patient cohort consisted of two groups: Group A consisted of 73 pregnant females who received iodinated contrast agent for CTPA, and Group B (control group) consisted of 42 pregnant females who were investigated by perfusion imaging only. The results of the neonatal thyroid function tests for the babies of the mothers in Groups A and B were compared. All of the neonatal thyroid function tests for both groups were normal with no statistical difference between the two groups. No adverse effect on thyroid function was demonstrated in neonates exposed to in utero iodinated contrast media. However, as our study involves a small patient group, the results should be interpreted with caution.
ISSN:0007-1285
1748-880X
DOI:10.1259/bjr/29806327