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Effect of antenatal iodinated contrast agent on neonatal thyroid function
The aim of this study was to assess the effect on neonatal thyroid function of iodinated contrast media administered for CT pulmonary angiography (CTPA) in babies whose mothers were investigated for suspected pulmonary embolism during pregnancy. Retrospective review of 115 pregnant patients investig...
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| Published in: | British journal of radiology 2012-07, Vol.85 (1015), p.e238-e242 |
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| container_end_page | e242 |
| container_issue | 1015 |
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| container_title | British journal of radiology |
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| creator | Rajaram, S Exley, C E Fairlie, F Matthews, S |
| description | The aim of this study was to assess the effect on neonatal thyroid function of iodinated contrast media administered for CT pulmonary angiography (CTPA) in babies whose mothers were investigated for suspected pulmonary embolism during pregnancy.
Retrospective review of 115 pregnant patients investigated for suspected pulmonary embolism. The patient cohort consisted of two groups: Group A consisted of 73 pregnant females who received iodinated contrast agent for CTPA, and Group B (control group) consisted of 42 pregnant females who were investigated by perfusion imaging only. The results of the neonatal thyroid function tests for the babies of the mothers in Groups A and B were compared.
All of the neonatal thyroid function tests for both groups were normal with no statistical difference between the two groups.
No adverse effect on thyroid function was demonstrated in neonates exposed to in utero iodinated contrast media. However, as our study involves a small patient group, the results should be interpreted with caution. |
| doi_str_mv | 10.1259/bjr/29806327 |
| format | article |
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Retrospective review of 115 pregnant patients investigated for suspected pulmonary embolism. The patient cohort consisted of two groups: Group A consisted of 73 pregnant females who received iodinated contrast agent for CTPA, and Group B (control group) consisted of 42 pregnant females who were investigated by perfusion imaging only. The results of the neonatal thyroid function tests for the babies of the mothers in Groups A and B were compared.
All of the neonatal thyroid function tests for both groups were normal with no statistical difference between the two groups.
No adverse effect on thyroid function was demonstrated in neonates exposed to in utero iodinated contrast media. However, as our study involves a small patient group, the results should be interpreted with caution.</description><identifier>ISSN: 0007-1285</identifier><identifier>EISSN: 1748-880X</identifier><identifier>DOI: 10.1259/bjr/29806327</identifier><identifier>PMID: 22167515</identifier><language>eng</language><publisher>England: The British Institute of Radiology</publisher><subject>Adult ; Angiography - adverse effects ; Angiography - methods ; Case-Control Studies ; Contrast Media - adverse effects ; Contrast Media - pharmacology ; Female ; Follow-Up Studies ; Gestational Age ; Humans ; Infant, Newborn ; Iodine Radioisotopes - adverse effects ; Male ; Neonatal Screening - methods ; Pregnancy ; Pregnancy Complications, Cardiovascular - diagnosis ; Pregnancy Complications, Cardiovascular - diagnostic imaging ; Prenatal Diagnosis - adverse effects ; Prenatal Diagnosis - methods ; Prenatal Exposure Delayed Effects - blood ; Prenatal Exposure Delayed Effects - chemically induced ; Pulmonary Embolism - diagnostic imaging ; Reference Values ; Retrospective Studies ; Risk Assessment ; Thyroid Function Tests ; Thyroid Gland - drug effects ; Tomography, X-Ray Computed - adverse effects ; Tomography, X-Ray Computed - methods</subject><ispartof>British journal of radiology, 2012-07, Vol.85 (1015), p.e238-e242</ispartof><rights>2012 The British Institute of Radiology 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-c1bd2d3f42223481202c2f3c87072025481d10ad840ef9f0dffe36b0aa5ab1da3</citedby><cites>FETCH-LOGICAL-c450t-c1bd2d3f42223481202c2f3c87072025481d10ad840ef9f0dffe36b0aa5ab1da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22167515$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rajaram, S</creatorcontrib><creatorcontrib>Exley, C E</creatorcontrib><creatorcontrib>Fairlie, F</creatorcontrib><creatorcontrib>Matthews, S</creatorcontrib><title>Effect of antenatal iodinated contrast agent on neonatal thyroid function</title><title>British journal of radiology</title><addtitle>Br J Radiol</addtitle><description>The aim of this study was to assess the effect on neonatal thyroid function of iodinated contrast media administered for CT pulmonary angiography (CTPA) in babies whose mothers were investigated for suspected pulmonary embolism during pregnancy.
Retrospective review of 115 pregnant patients investigated for suspected pulmonary embolism. The patient cohort consisted of two groups: Group A consisted of 73 pregnant females who received iodinated contrast agent for CTPA, and Group B (control group) consisted of 42 pregnant females who were investigated by perfusion imaging only. The results of the neonatal thyroid function tests for the babies of the mothers in Groups A and B were compared.
All of the neonatal thyroid function tests for both groups were normal with no statistical difference between the two groups.
No adverse effect on thyroid function was demonstrated in neonates exposed to in utero iodinated contrast media. However, as our study involves a small patient group, the results should be interpreted with caution.</description><subject>Adult</subject><subject>Angiography - adverse effects</subject><subject>Angiography - methods</subject><subject>Case-Control Studies</subject><subject>Contrast Media - adverse effects</subject><subject>Contrast Media - pharmacology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Iodine Radioisotopes - adverse effects</subject><subject>Male</subject><subject>Neonatal Screening - methods</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Cardiovascular - diagnosis</subject><subject>Pregnancy Complications, Cardiovascular - diagnostic imaging</subject><subject>Prenatal Diagnosis - adverse effects</subject><subject>Prenatal Diagnosis - methods</subject><subject>Prenatal Exposure Delayed Effects - blood</subject><subject>Prenatal Exposure Delayed Effects - chemically induced</subject><subject>Pulmonary Embolism - diagnostic imaging</subject><subject>Reference Values</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Thyroid Function Tests</subject><subject>Thyroid Gland - drug effects</subject><subject>Tomography, X-Ray Computed - adverse effects</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>0007-1285</issn><issn>1748-880X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNpVUE1PAjEQbYxGEL15NvsDXJl-sd2LiSGoJCReNPHWdPsBJdCS3WLCv6cEIXqaNzNv3rw8hO4xPGHC62GzbIekFjCipLpAfVwxUQoB35eoDwBViYngPXTTdctDy2u4Rj1C8KjimPfRdOKc1amIrlAh2aCSWhU-Gp-RNYWOIbWqS4Wa25BZoQg2HklpsWujN4XbBp18DLfoyqlVZ-9-6wB9vU4-x-_l7ONtOn6ZlZpxSKXGjSGGOkYIoUxgAkQTR7WooMqY55HBoIxgYF3twGR_dNSAUlw12Cg6QM9H3c22WVuj7cHhSm5av1btTkbl5f9N8As5jz-SsooBE1ng8Sig29h1rXXnWwzyEKnMkcpTpJn-8PffmXzKkO4B9v90Ng</recordid><startdate>201207</startdate><enddate>201207</enddate><creator>Rajaram, S</creator><creator>Exley, C E</creator><creator>Fairlie, F</creator><creator>Matthews, S</creator><general>The British Institute of Radiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>201207</creationdate><title>Effect of antenatal iodinated contrast agent on neonatal thyroid function</title><author>Rajaram, S ; Exley, C E ; Fairlie, F ; Matthews, S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-c1bd2d3f42223481202c2f3c87072025481d10ad840ef9f0dffe36b0aa5ab1da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Angiography - adverse effects</topic><topic>Angiography - methods</topic><topic>Case-Control Studies</topic><topic>Contrast Media - adverse effects</topic><topic>Contrast Media - pharmacology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Iodine Radioisotopes - adverse effects</topic><topic>Male</topic><topic>Neonatal Screening - methods</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Cardiovascular - diagnosis</topic><topic>Pregnancy Complications, Cardiovascular - diagnostic imaging</topic><topic>Prenatal Diagnosis - adverse effects</topic><topic>Prenatal Diagnosis - methods</topic><topic>Prenatal Exposure Delayed Effects - blood</topic><topic>Prenatal Exposure Delayed Effects - chemically induced</topic><topic>Pulmonary Embolism - diagnostic imaging</topic><topic>Reference Values</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Thyroid Function Tests</topic><topic>Thyroid Gland - drug effects</topic><topic>Tomography, X-Ray Computed - adverse effects</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rajaram, S</creatorcontrib><creatorcontrib>Exley, C E</creatorcontrib><creatorcontrib>Fairlie, F</creatorcontrib><creatorcontrib>Matthews, S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rajaram, S</au><au>Exley, C E</au><au>Fairlie, F</au><au>Matthews, S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of antenatal iodinated contrast agent on neonatal thyroid function</atitle><jtitle>British journal of radiology</jtitle><addtitle>Br J Radiol</addtitle><date>2012-07</date><risdate>2012</risdate><volume>85</volume><issue>1015</issue><spage>e238</spage><epage>e242</epage><pages>e238-e242</pages><issn>0007-1285</issn><eissn>1748-880X</eissn><abstract>The aim of this study was to assess the effect on neonatal thyroid function of iodinated contrast media administered for CT pulmonary angiography (CTPA) in babies whose mothers were investigated for suspected pulmonary embolism during pregnancy.
Retrospective review of 115 pregnant patients investigated for suspected pulmonary embolism. The patient cohort consisted of two groups: Group A consisted of 73 pregnant females who received iodinated contrast agent for CTPA, and Group B (control group) consisted of 42 pregnant females who were investigated by perfusion imaging only. The results of the neonatal thyroid function tests for the babies of the mothers in Groups A and B were compared.
All of the neonatal thyroid function tests for both groups were normal with no statistical difference between the two groups.
No adverse effect on thyroid function was demonstrated in neonates exposed to in utero iodinated contrast media. However, as our study involves a small patient group, the results should be interpreted with caution.</abstract><cop>England</cop><pub>The British Institute of Radiology</pub><pmid>22167515</pmid><doi>10.1259/bjr/29806327</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0007-1285 |
| ispartof | British journal of radiology, 2012-07, Vol.85 (1015), p.e238-e242 |
| issn | 0007-1285 1748-880X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3474048 |
| source | Oxford Journals Online; Alma/SFX Local Collection |
| subjects | Adult Angiography - adverse effects Angiography - methods Case-Control Studies Contrast Media - adverse effects Contrast Media - pharmacology Female Follow-Up Studies Gestational Age Humans Infant, Newborn Iodine Radioisotopes - adverse effects Male Neonatal Screening - methods Pregnancy Pregnancy Complications, Cardiovascular - diagnosis Pregnancy Complications, Cardiovascular - diagnostic imaging Prenatal Diagnosis - adverse effects Prenatal Diagnosis - methods Prenatal Exposure Delayed Effects - blood Prenatal Exposure Delayed Effects - chemically induced Pulmonary Embolism - diagnostic imaging Reference Values Retrospective Studies Risk Assessment Thyroid Function Tests Thyroid Gland - drug effects Tomography, X-Ray Computed - adverse effects Tomography, X-Ray Computed - methods |
| title | Effect of antenatal iodinated contrast agent on neonatal thyroid function |
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