Triple Stimulus-Responsive Polypeptide Nanoparticles That Enhance Intratumoral Spatial Distribution

To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical mic...

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Bibliographic Details
Published in:Nano letters 2012-04, Vol.12 (4), p.2165-2170
Main Authors: Callahan, Daniel J, Liu, Wenge, Li, Xinghai, Dreher, Matthew R, Hassouneh, Wafa, Kim, Minkyu, Marszalek, Piotr, Chilkoti, Ashutosh
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biomedical materials
Biotechnology
Cross-disciplinary physics: materials science
rheology
Drug Carriers - analysis
Drug Carriers - chemistry
Drug Carriers - metabolism
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Histidine - chemistry
Hydrogen-Ion Concentration
In vivo testing
In vivo tests
Materials science
Methods. Procedures. Technologies
Micelles
Nanocrystalline materials
Nanoparticles
Nanoparticles - chemistry
Nanoscale materials and structures: fabrication and characterization
Neoplasms - metabolism
Others
Penetration
Peptides - analysis
Peptides - metabolism
Physics
Polypeptides
Tumors
Various methods and equipments
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Summary:To address the limited tumor penetration of nanoparticle drug delivery vehicles, we report the first pH-responsive polypeptide micelle that dissociates at the low extracellular pH of solid tumors. This histidine-rich elastin-like polypeptide block copolymer self-assembles at 37 °C into spherical micelles that are stabilized by Zn2+ and are disrupted as the pH drops from 7.4 to 6.4. These pH-sensitive micelles demonstrate better in vivo penetration and distribution in tumors than a pH-insensitive control.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl300630c