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Epiphany root canal sealer prepared with resinous solvent is irritating to rat subcutaneous tissues

This study assessed the biocompatibility of the Epiphany endodontic sealer prepared with resinous solvent of Epiphany system (Thinning resin) in rat subcutaneous tissues. Polyethylene tubes were filled with the sealer and 4 groups were established: GI, Epiphany prepared with 1 drop of resinous solve...

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Bibliographic Details
Published in:Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2012-07, Vol.17 (4), p.e716-e720
Main Authors: Daleffe, Élcio, Vieira-Ozório, José-Estevam, Sousa-Neto, José-Estevam, da-Cruz-Perez, Danyel-Elias
Format: Article
Language:English
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Summary:This study assessed the biocompatibility of the Epiphany endodontic sealer prepared with resinous solvent of Epiphany system (Thinning resin) in rat subcutaneous tissues. Polyethylene tubes were filled with the sealer and 4 groups were established: GI, Epiphany prepared with 1 drop of resinous solvent (RS); GII, Epiphany prepared with 1 drop of RS and photoactivated; GIII, Epiphany associated with self-etch primer and prepared with 1 drop of RS; GIV, Epiphany associated with self-etch primer, prepared with 1 drop of RS and photoactivated. The filled tubes were implanted into 4 different regions of the dorsum of 20 adult male rats. After 7, 14 and 21 days, all groups presented a moderate to severe chronic inflammation, necrosis and foreign-body giant cells. At 42 days, although the intensity of chronic inflammatory reaction decreased, the other features still were observed. The Epiphany sealer prepared with the RS was irritating to rat subcutaneous tissues.
ISSN:1698-6946
1698-4447
1698-6946
DOI:10.4317/medoral.17788