Effects of perfluorooctanoic acid on mouse mammary gland development and differentiation resulting from cross-foster and restricted gestational exposures

The adverse consequences of developmental exposures to perfluorooctanoic acid (PFOA) are established in mice, and include impaired development of the mammary gland (MG). However, the relationships between timing or route of exposure, and consequences in the MG have not been characterized. To address...

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Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2009-06, Vol.27 (3-4), p.289-298
Main Authors: White, Sally S., Kato, Kayoko, Jia, Lily T., Basden, Brian J., Calafat, Antonia M., Hines, Erin P., Stanko, Jason P., Wolf, Cynthia J., Abbott, Barbara D., Fenton, Suzanne E.
Format: Article
Language:English
Subjects:
Animals
Caprylates - administration & dosage
Caprylates - toxicity
Delayed development
Dosimetry
Environmental Pollutants - administration & dosage
Environmental Pollutants - toxicity
Female
Fetal Development - drug effects
Fetal origins of adult disease
Fluorocarbons - administration & dosage
Fluorocarbons - toxicity
Gestational Age
Lactation
Mammary gland
Mammary Glands, Animal - drug effects
Mammary Glands, Animal - growth & development
Maternal Deprivation
Maternal Exposure
Mice
Mice, Inbred Strains
Neonatal exposure
Perfluorooctanoic acid (PFOA)
Pregnancy
Prenatal exposure
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Summary:The adverse consequences of developmental exposures to perfluorooctanoic acid (PFOA) are established in mice, and include impaired development of the mammary gland (MG). However, the relationships between timing or route of exposure, and consequences in the MG have not been characterized. To address the effects of these variables on the onset and persistence of MG effects in female offspring, timed pregnant CD-1 dams received PFOA by oral gavage over various gestational durations. Cross-fostering studies identified the 5mg/kg dose, under either lactational- or intrauterine-only exposures, to delay MG development as early as postnatal day (PND) 1, persisting beyond PND 63. Intrauterine exposure during the final days of pregnancy caused adverse MG developmental effects similar to that of extended gestational exposures. These studies confirm a window of MG sensitivity in late fetal and early neonatal life, and demonstrate developmental PFOA exposure results in early and persistent MG effects, suggesting permanent consequences.
ISSN:0890-6238
1873-1708
DOI:10.1016/j.reprotox.2008.11.054