Acoustic Droplet Vaporization and Propulsion of Perfluorocarbon-Loaded Microbullets for Targeted Tissue Penetration and Deformation

Bullets and rockets: Ultrasound‐triggered vaporization of a perfluorocarbon compound loaded into microbullets provides the necessary force for the microbullets to penetrate, cleave, and deform cellular tissue for potential targeted drug delivery and precision nanosurgery. The microbullets have an in...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2012-07, Vol.51 (30), p.7519-7522
Main Authors: Kagan, Daniel, Benchimol, Michael J., Claussen, Jonathan C., Chuluun-Erdene, Erdembileg, Esener, Sadik, Wang, Joseph
Format: Article
Language:English
Subjects:
Acoustics
Animals
Cellular
Conjugation
Deformation
Droplets
Drug Carriers - chemistry
drug delivery
Drug delivery systems
Drug Delivery Systems - instrumentation
electrostatic interactions
Emulsions - chemistry
Fluorocarbons - chemistry
Kidney - metabolism
Nanostructure
perfluorinated solvents
Perfluorocarbons
Projectiles
Sheep
Solubility
Static Electricity
Ultrasonics
ultrasound
Vaporization
Volatilization
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Summary:Bullets and rockets: Ultrasound‐triggered vaporization of a perfluorocarbon compound loaded into microbullets provides the necessary force for the microbullets to penetrate, cleave, and deform cellular tissue for potential targeted drug delivery and precision nanosurgery. The microbullets have an inner Au layer that allows conjugation of a monolayer of thiolated cysteamine (green in picture) for electrostatic attachment of perfluorocarbon droplets (purple droplets).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201201902