Complement-dependent transport of antigen into B cell follicles

Since the original proposal by Fearon and Locksley (Fearon and Locksley. 1996. Science 272: 50-53) that the complement system linked innate and adaptive immunity, there has been a rapid expansion of studies on this topic. With the advance of intravital imaging, a number of recent papers revealed an...

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Bibliographic Details
Published in:The Journal of immunology (1950) 2010-09, Vol.185 (5), p.2659-2664
Main Authors: Gonzalez, Santiago F, Lukacs-Kornek, Veronika, Kuligowski, Michael P, Pitcher, Lisa A, Degn, Søren E, Turley, Shannon J, Carroll, Michael C
Format: Article
Language:English
Subjects:
Animals
Antigens - metabolism
B-Lymphocyte Subsets - immunology
B-Lymphocyte Subsets - metabolism
B-Lymphocyte Subsets - virology
Cell Compartmentation - immunology
Complement System Proteins - physiology
Dendritic Cells - immunology
Dendritic Cells - metabolism
Dendritic Cells - virology
Humans
Lymphoid Tissue - cytology
Lymphoid Tissue - immunology
Lymphoid Tissue - metabolism
Protein Transport - immunology
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Summary:Since the original proposal by Fearon and Locksley (Fearon and Locksley. 1996. Science 272: 50-53) that the complement system linked innate and adaptive immunity, there has been a rapid expansion of studies on this topic. With the advance of intravital imaging, a number of recent papers revealed an additional novel pathway in which complement C3 and its receptors enhance humoral immunity through delivery of Ag to the B cell compartment. In this review, we discuss this pathway and highlight several novel exceptions recently found with a model influenza vaccine, such as mannose-binding lectin opsonization of influenza and uptake by macrophages, and the capture of virus by dendritic cells residing in the medullary compartment of peripheral lymph nodes.
ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.1000522