Wnt signaling in myogenesis

The formation of skeletal muscle is a tightly regulated process that is critically modulated by Wnt signaling. Myogenesis is dependent on the precise and dynamic integration of multiple Wnt signals allowing self-renewal and progression of muscle precursors in the myogenic lineage. Dysregulation of W...

Full description

Saved in:
Bibliographic Details
Published in:Trends in cell biology 2012-11, Vol.22 (11), p.602-609
Main Authors: von Maltzahn, Julia, Chang, Natasha C, Bentzinger, C. Florian, Rudnicki, Michael A
Format: Article
Language:English
Subjects:
Animals
Frizzled
Heart - embryology
Humans
Muscle Development
Myocardium - metabolism
myofiber
myogenesis
Pathology
satellite cell
Signal Transduction
skeletal muscle
Wnt
Wnt Proteins - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The formation of skeletal muscle is a tightly regulated process that is critically modulated by Wnt signaling. Myogenesis is dependent on the precise and dynamic integration of multiple Wnt signals allowing self-renewal and progression of muscle precursors in the myogenic lineage. Dysregulation of Wnt signaling can lead to severe developmental defects and perturbation of muscle homeostasis. Recent work has revealed novel roles for the non-canonical planar cell polarity (PCP) and AKT/mTOR pathways in mediating the effects of Wnt on skeletal muscle. In this review, we discuss the role of Wnt signaling in myogenesis and in regulating the homeostasis of adult muscle.
ISSN:0962-8924
1879-3088
DOI:10.1016/j.tcb.2012.07.008