Evaluation of breast amorphous calcifications by a computer-aided detection system in full-field digital mammography

The purpose of this study was to evaluate the performance of a direct computer-aided detection (d-CAD) system integrated with full-field digital mammography (FFDM) in assessment of amorphous calcifications. From 1438 consecutive stereotactic-guided biopsies, FFDM images with amorphous calcifications...

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Bibliographic Details
Published in:British journal of radiology 2012-05, Vol.85 (1013), p.517-522
Main Authors: SCARANELO, A. M, EIADA, R, BUKHANOV, K, CRYSTAL, P
Format: Article
Language:English
Subjects:
Adult
Age
Aged
Aged, 80 and over
Benign
Biological and medical sciences
Biopsy
Breast cancer
Breast Diseases - diagnostic imaging
Breast Neoplasms - diagnostic imaging
Calcification
Calcinosis - diagnostic imaging
Computerized, statistical medical data processing and models in biomedicine
Female
Genital system. Mammary gland
Humans
Investigative techniques, diagnostic techniques (general aspects)
Malignancy
Mammography
Mammography - methods
Medical management aid. Diagnosis aid
Medical sciences
Middle Aged
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Radiographic Image Interpretation, Computer-Assisted - methods
Regression analysis
Retrospective Studies
Risk factors
Risk groups
Sensitivity and Specificity
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Summary:The purpose of this study was to evaluate the performance of a direct computer-aided detection (d-CAD) system integrated with full-field digital mammography (FFDM) in assessment of amorphous calcifications. From 1438 consecutive stereotactic-guided biopsies, FFDM images with amorphous calcifications were selected for retrospective evaluation by d-CAD in 122 females (mean age, 56 years; range, 35-84 years). The sensitivity, specificity, accuracy and false-positive rate of the d-CAD system were calculated in the total group of 124 lesions and in the subgroups based on breast density, mammographic lesion distribution and extension. Logistic regression analysis was used to stratify the risk of malignancy by patient risk factors and age. The d-CAD marked all (36/36) breast cancers, 85% (11/13) of the high-risk lesions and 80% (60/75) of benign amorphous calcifications (p0.05); however, d-CAD marks showed differences for small (
ISSN:0007-1285
1748-880X
DOI:10.1259/bjr/31850970