Diabetes and Cardiovascular Disease: Changing the Focus from Glycemic Control to Improving Long-Term Survival

Diabetes mellitus (DM) is the fifth-leading cause of death worldwide and contributes to leading causes of death, cancer and cardiovascular disease, including CAD, stroke, peripheral vascular disease, and other vascular disease. While glycemic management remains a cornerstone of DM care, the co-manag...

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Bibliographic Details
Published in:The American journal of cardiology 2012-11, Vol.110 (9), p.58B-68B
Main Authors: Wang, Cecilia C. Low, MD, Reusch, Jane E.B., MD
Format: Article
Language:English
Subjects:
Albuminuria - prevention & control
Anticholesteremic Agents - therapeutic use
Antihypertensive Agents - therapeutic use
Cardiovascular
Cardiovascular disease
Cardiovascular Diseases - etiology
Cardiovascular Diseases - mortality
Cardiovascular Diseases - prevention & control
Cholesterol
Diabetes
Diabetes Complications - mortality
Diabetes Complications - physiopathology
Diabetes Complications - therapy
Exercise Therapy
Heart attacks
Humans
Hyperglycemia - etiology
Hyperglycemia - prevention & control
Hypertension
Mortality
Risk Factors
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Summary:Diabetes mellitus (DM) is the fifth-leading cause of death worldwide and contributes to leading causes of death, cancer and cardiovascular disease, including CAD, stroke, peripheral vascular disease, and other vascular disease. While glycemic management remains a cornerstone of DM care, the co-management of hypertension, atherosclerosis, cardiovascular risk reduction, and prevention of long-term consequences associated with DM are now well recognized as essential to improve long-term survival. Clinical trial evidence substantiates the importance of glycemic control, low-density cholesterol–lowering therapy, blood pressure lowering, control of albuminuria, and comprehensive approaches targeting multiple risk factors to reduce cardiovascular risk. This article presents a review of the role of DM in the pathogenesis of atherosclerosis and cardiac dysfunction, recent evidence on the degree of glycemic control and mortality, and available evidence for a multifaceted approach to improve long-term outcomes for patients.
ISSN:0002-9149
1879-1913
1879-1913
DOI:10.1016/j.amjcard.2012.08.036