Effect of Tinospora cordifolia on experimental diabetic neuropathy

To evaluate the effect of aqueous extract of stem of Tinospora cordifolia (TC) on hyperalgesia in streptozotocin induced diabetic rats and in- vitro aldose reductase inhibition. Wistar albino rats, rendered diabetic with streptozotocin, were divided into 5 groups, namely the diabetic control treated...

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Published in:Indian journal of pharmacology 2012-09, Vol.44 (5), p.580-583
Main Authors: Nadig, Pratibha D, Revankar, Roshni R, Dethe, Shankar M, Narayanswamy, Sriniwas B, Aliyar, Meharban A
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Development and progression
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - drug therapy
Diabetes therapy
Diabetic neuropathies
Diabetic Neuropathies - blood
Diabetic Neuropathies - drug therapy
Diabetic neuropathy
Female
Herbal medicine
Pain Measurement - drug effects
Pain Measurement - methods
Pharmacology
Physiological aspects
Plant Bark
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Rats
Rats, Wistar
Tinospora
Treatment Outcome
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Summary:To evaluate the effect of aqueous extract of stem of Tinospora cordifolia (TC) on hyperalgesia in streptozotocin induced diabetic rats and in- vitro aldose reductase inhibition. Wistar albino rats, rendered diabetic with streptozotocin, were divided into 5 groups, namely the diabetic control treated with vehicle (DC), standard control which received glibenclamide+metformin (SC), test groups treated with 100, 200and 400 mg/kg b.w. of Tinospora cordifolia (TC1, TC2 and TC3 respectively). A group of five normal animals served as normal control (NC). Fasting blood glucose, body weight and reaction time to tail flick were measured one week after induction of diabetes. The animals were then treated orally for two weeks after which the same parameters were repeated. In-vitro aldose reductase inhibition assay was carried out at concentrations of 5, 10, 25, 50, 100 and 200 mcg/ml of Tinospora cordifolia using rat lens from normal rats. The in-vivo results were analysed with Mann Whitney test. The DC group demonstrated a decrease in the reaction time (hyperalgesia) compared to NC while a significant increase in the reaction time was observed with SC, TC2 and TC3 groups (p
ISSN:0253-7613
1998-3751
DOI:10.4103/0253-7613.100380