A new eye on NLR proteins: focused on clarity or diffused by complexity?

Highlights ► We discuss recent advances in understanding animal and plant NLRs in a comparative fashion. ► P-loop-dependent and independent modes of activation are highlighted. ► We review evidence for homo- and hetero-dimerization requirements for NLR functions. ► We discuss unconventional function...

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Bibliographic Details
Published in:Current opinion in immunology 2012-02, Vol.24 (1), p.41-50
Main Authors: Bonardi, Vera, Cherkis, Karen, Nishimura, Marc T, Dangl, Jeffery L
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Apoptosis - immunology
Carrier Proteins - immunology
Humans
Immunity, Innate - immunology
Multigene Family
Nod Signaling Adaptor Proteins - physiology
Plant Proteins - immunology
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Summary:Highlights ► We discuss recent advances in understanding animal and plant NLRs in a comparative fashion. ► P-loop-dependent and independent modes of activation are highlighted. ► We review evidence for homo- and hetero-dimerization requirements for NLR functions. ► We discuss unconventional functions for plant NLRs beyond pathogen effector recognition. ► We describe nuclear-cytoplasmic partitioning requirement for NLRs across the two kingdoms.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2011.12.006