Protective Effects of the Traditional Herbal Formula Oryeongsan Water Extract on Ethanol-Induced Acute Gastric Mucosal Injury in Rats

This study was performed to evaluate the protective effect and safety of Oryeongsan water extract (OSWE) on ethanol-induced acute gastric mucosal injury and an acute toxicity study in rats. Acute gastric lesions were induced via intragastric oral administration of absolute ethanol at a dose of 5 mL/...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2012-01, Vol.2012 (2012), p.1-9
Main Authors: Lim, Hye-Sun, Shin, In-Shik, Lee, Mi-Young, Jeon, Woo-Young, Shin, Hyeun-Kyoo
Format: Article
Language:English
Subjects:
Acute toxicity
Animal models
Antioxidants
Biochemistry
Edema
Enzymes
Epithelial cells
Ethanol
Free radicals
Gastric mucosa
Glutathione
Hemorrhage
Herbal medicine
Herbs
Hyperemia
Laboratory animals
Lesions
Lipid peroxidation
Lipids
Malondialdehyde
Medical research
Medicine
Mucous membrane
Oral administration
Oxidative stress
Polyporus
Rats
Rodents
Stomach
Toxicology
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Summary:This study was performed to evaluate the protective effect and safety of Oryeongsan water extract (OSWE) on ethanol-induced acute gastric mucosal injury and an acute toxicity study in rats. Acute gastric lesions were induced via intragastric oral administration of absolute ethanol at a dose of 5 mL/kg. OSWE (100 and 200 mg/kg) was administered to rats 2 h prior to the oral administration of absolute ethanol. The stomach of animal models was opened and gastric mucosal lesions were examined. Gastric mucosal injuries were evaluated by measuring the levels of malondialdehyde (MDA), glutathione (GSH), and the activity of antioxidant enzymes. In the acute toxicity study, no adverse effects of OSWE were observed at doses up to 2000 mg/kg/day. Administration of OSWE reduced the damage by conditioning the gastric mucosa against ethanol-induced acute gastric injury, which included hemorrhage, hyperemia, and loss of epithelial cells. The level of MDA was reduced in OSWE-treated groups compared with the ethanol-induced group. Moreover, the level of GSH and the activity of antioxidant enzymes were significantly increased in the OSWE-treated groups. Our findings suggest that OSWE has a protective effect on the gastric mucosa against ethanol-induced acute gastric injury via the upregulation of antioxidant enzymes.
ISSN:1741-427X
1741-4288
DOI:10.1155/2012/438191