Age-dependent effects of carotid endarterectomy or stenting on cognitive performance

Although evidence is accumulating that age modifies the risk of carotid angioplasty and stenting (CAS) versus endarterectomy (CEA) for patients with significant carotid stenosis, the impact of age on cognition after either CEA or CAS remains unclear. In this study, we analyzed the effects of age on...

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Bibliographic Details
Published in:Journal of neurology 2012-11, Vol.259 (11), p.2309-2318
Main Authors: Wasser, Katrin, Hildebrandt, Helmut, Gröschel, Sonja, Stojanovic, Tomislav, Schmidt, Holger, Gröschel, Klaus, Pilgram-Pastor, Sara M., Knauth, Michael, Kastrup, Andreas
Format: Article
Language:English
Subjects:
Age
Age Factors
Aged
Angioplasty
Angioplasty, Balloon - adverse effects
Angioplasty, Balloon - psychology
Asymptomatic
Biological and medical sciences
Carcinoembryonic antigen
Carotid arteries
Carotid Stenosis - epidemiology
Carotid Stenosis - psychology
Carotid Stenosis - surgery
Cognition & reasoning
Cognition Disorders - epidemiology
Cognition Disorders - psychology
Cognitive ability
Endarterectomy, Carotid - adverse effects
Endarterectomy, Carotid - psychology
Female
Humans
Ischemia
Learning
Magnetic resonance imaging
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Neurology
Neuropharmacology
Neuroprotective agent
Neuropsychological Tests
Neuropsychology
Neuroradiology
Neurosciences
Original Communication
Pharmacology. Drug treatments
Retrospective Studies
Stenosis
Stents - adverse effects
Treatment Outcome
Ultrasonic imaging
Veins & arteries
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Description
Summary:Although evidence is accumulating that age modifies the risk of carotid angioplasty and stenting (CAS) versus endarterectomy (CEA) for patients with significant carotid stenosis, the impact of age on cognition after either CEA or CAS remains unclear. In this study, we analyzed the effects of age on cognitive performance after either CEA or CAS using a comprehensive neuropsychological test battery with parallel test forms and a control group to exclude a learning effect. The neuropsychological outcomes after revascularization were determined in 19 CAS and 27 CEA patients with severe carotid stenosis. The patients were subdivided according to their median age (
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-012-6491-9