Replication of the scrapie agent in ocular neural tissues [Hamsters]

Optic nerves and retinas removed from hamsters experimentally inoculated with the scrapie agent contain a high titer of infectivity. Ophthalmoscopic examination of these animals revealed gross lesions of retinopathy as early as 3 weeks before the onset of clinical signs of brain degeneration. These...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1980-02, Vol.77 (2), p.1169-1171
Main Authors: Buyukmihci, Ned, Rorvik, Marie, Marsh, Richard F.
Format: Article
Language:English
Subjects:
Animals
Brain
Brain - microbiology
Cricetinae
Infections
Inoculation
Lesions
Male
Nerve tissue
Nerves
Optic nerve
Optic Nerve - microbiology
Optic nerve diseases
Prions - growth & development
Retina
Retina - microbiology
Retina - ultrastructure
Scrapie - microbiology
Sheep
Time Factors
Virus Replication
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Description
Summary:Optic nerves and retinas removed from hamsters experimentally inoculated with the scrapie agent contain a high titer of infectivity. Ophthalmoscopic examination of these animals revealed gross lesions of retinopathy as early as 3 weeks before the onset of clinical signs of brain degeneration. These results suggest that the scrapie agent may spread centrifugally in nerve fibers after intracerebral inoculation and that the scrapie-associated retinopathy seen in hamsters is directly induced by the agent rather than the result of retrograde degeneration from central neural damage.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.77.2.1169