Effector Memory T cells Are Associated With Atherosclerosis in Humans and Animal Models

BackgroundAdaptive T‐cell response is promoted during atherogenesis and results in the differentiation of naïve CD4+T cells to effector and/or memory cells of specialized T‐cell subsets. Aim of this work was to investigate the relationship between circulating CD4+T‐cell subsets and atherosclerosis....

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Published in:Journal of the American Heart Association 2012-02, Vol.1 (1), p.27-n/a
Main Authors: Ammirati, Enrico, Cianflone, Domenico, Vecchio, Viviana, Banfi, Michela, Vermi, Anna C., De Metrio, Monica, Grigore, Liliana, Pellegatta, Fabio, Pirillo, Angela, Garlaschelli, Katia, Manfredi, Angelo A., Catapano, Alberico L., Maseri, Attilio, Palini, Alessio G., Norata, Giuseppe D.
Format: Article
Language:English
Subjects:
atherosclerosis
chemokines
coronary artery disease
C‐c chemokine receptor type 7
effector memory T cells
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Summary:BackgroundAdaptive T‐cell response is promoted during atherogenesis and results in the differentiation of naïve CD4+T cells to effector and/or memory cells of specialized T‐cell subsets. Aim of this work was to investigate the relationship between circulating CD4+T‐cell subsets and atherosclerosis. Methods and ResultsWe analyzed 57 subsets of circulating CD4+T cells by 10‐parameter/8‐color polychromatic flow cytometry (markers: CD3/CD4/CD45RO/CD45RA/CCR7/CCR5/CXCR3/HLA‐DR) in peripheral blood from 313 subjects derived from 2 independent cohorts. In the first cohort of subjects from a free‐living population (n=183), effector memory T cells (TEM: CD3+CD4+CD45RA−CD45RO+CCR7− cells) were strongly related with intima‐media thickness of the common carotid artery, even after adjustment for age (r=0.27; P
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.111.000125