New insights on the role of CD8+CD57+ T-cells in cancer

Incomplete differentiation of CD8 + cytotoxic T-lymphocytes (CTLs) in the tumor microenvironment is associated with cancer progression. We describe a new type of tumor-infiltrating CD8 + CD57 + T cell in cancer with hybrid phenotypic and functional properties of both an early effector-memory cell an...

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Bibliographic Details
Published in:Oncoimmunology 2012-09, Vol.1 (6), p.954-956
Main Authors: Wu, Richard C., Hwu, Patrick, Radvanyi, Laszlo G.
Format: Article
Language:English
Subjects:
Author's View
Binding
Biology
Bioscience
Calcium
Cancer
CD57
CD8
Cell
CTL
Cycle
effector-memory
Landes
melanoma
Organogenesis
Proteins
tumor-infiltrating lymphocytes
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Summary:Incomplete differentiation of CD8 + cytotoxic T-lymphocytes (CTLs) in the tumor microenvironment is associated with cancer progression. We describe a new type of tumor-infiltrating CD8 + CD57 + T cell in cancer with hybrid phenotypic and functional properties of both an early effector-memory cell and a terminally-differentiated effector cell. These cells behave as incompletely-differentiated CTLs.
ISSN:2162-4011
2162-402X
2162-402X
DOI:10.4161/onci.20307