Cytogenetic abnormalities in 222 infertile men with azoospermia and oligospermia in Iran: Report and review

Infertility affects approximately 10%-15% of couples in reproductive age. In half of the couples, causes are male-related, associated with impaired spermatogenesis. There is a complex correlation between genetics and infertility. Several factors affect on gametogenesis, from which factors that lead...

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Bibliographic Details
Published in:Indian journal of human genetics 2012-05, Vol.18 (2), p.198-203
Main Authors: Akbari, Mohammad T, Behjati, F, Pourmand, G R, Asbagh, F Akbari, Kachoui, M Ataei
Format: Article
Language:English
Subjects:
Age
Chromosome abnormalities
Cytogenetics
Gametogenesis
Genetic aspects
Infertility
Infertility, Male
Literature reviews
Males
Original
Reviews
Risk factors
Sperm
Spermatogenesis
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Summary:Infertility affects approximately 10%-15% of couples in reproductive age. In half of the couples, causes are male-related, associated with impaired spermatogenesis. There is a complex correlation between genetics and infertility. Several factors affect on gametogenesis, from which factors that lead to chromosomal abnormalities are one of the best known. The aim of this study was to determine type and rate of chromosomal abnormalities in infertile azoospermic and oligospermic males in Iranian population. The records of a total of 222 participants were evaluated retrospectively. As a whole we observed 13.96% chromosomal abnormality, from which 12.15% showed numerical and 1.8% showed structural abnormalities. Comparison of our results with the review of the literature shows a higher incidence (4- fold) of gonosomal, in particular, numerical gonosomal, chromosomal anomalies. Cytogenetic analysis is strongly suggested for infertile men, particularly in those who suffer from azoospermia.
ISSN:0971-6866
1998-362X
DOI:10.4103/0971-6866.100764