Cytogenetic abnormalities in 222 infertile men with azoospermia and oligospermia in Iran: Report and review

Infertility affects approximately 10%-15% of couples in reproductive age. In half of the couples, causes are male-related, associated with impaired spermatogenesis. There is a complex correlation between genetics and infertility. Several factors affect on gametogenesis, from which factors that lead...

Full description

Saved in:
Bibliographic Details
Published in:Indian journal of human genetics 2012-05, Vol.18 (2), p.198-203
Main Authors: Akbari, Mohammad T, Behjati, F, Pourmand, G R, Asbagh, F Akbari, Kachoui, M Ataei
Format: Article
Language:English
Subjects:
Age
Chromosome abnormalities
Cytogenetics
Gametogenesis
Genetic aspects
Infertility
Infertility, Male
Literature reviews
Males
Original
Reviews
Risk factors
Sperm
Spermatogenesis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c4774-ff4f6b2d4c5486b61abd896acc8a79d25d69fdb7479f3824285047e8877e17673
cites
container_end_page 203
container_issue 2
container_start_page 198
container_title Indian journal of human genetics
container_volume 18
creator Akbari, Mohammad T
Behjati, F
Pourmand, G R
Asbagh, F Akbari
Kachoui, M Ataei
description Infertility affects approximately 10%-15% of couples in reproductive age. In half of the couples, causes are male-related, associated with impaired spermatogenesis. There is a complex correlation between genetics and infertility. Several factors affect on gametogenesis, from which factors that lead to chromosomal abnormalities are one of the best known. The aim of this study was to determine type and rate of chromosomal abnormalities in infertile azoospermic and oligospermic males in Iranian population. The records of a total of 222 participants were evaluated retrospectively. As a whole we observed 13.96% chromosomal abnormality, from which 12.15% showed numerical and 1.8% showed structural abnormalities. Comparison of our results with the review of the literature shows a higher incidence (4- fold) of gonosomal, in particular, numerical gonosomal, chromosomal anomalies. Cytogenetic analysis is strongly suggested for infertile men, particularly in those who suffer from azoospermia.
doi_str_mv 10.4103/0971-6866.100764
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3491294</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A302431494</galeid><sourcerecordid>A302431494</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4774-ff4f6b2d4c5486b61abd896acc8a79d25d69fdb7479f3824285047e8877e17673</originalsourceid><addsrcrecordid>eNqFkt1rFDEUxYModtv67pMM-OLLrPnafPgglMVqoVAQC76FTObONnUmWZPZlvrXm-nW1ZYFyUMg93cuN-cehF4TPOcEs_dYS1ILJcScYCwFf4ZmRGtVM0G_P0ezXfkAHeZ8jTFllOuX6IAyIijVYoZ-LO_GuIIAo3eVbUJMg-396CFXPlSU0nJ1kEbfQzVAqG79eFXZXzHmNaTB28qGtoq9X-0eiuws2fCh-grrmMZ7IMGNh9tj9KKzfYZXD_cRujz99G35pT6_-Hy2PDmvHZeS113HO9HQlrsFV6IRxDat0sI6p6zULV20QndtI7nUHVOUU7XAXIJSUgKRQrIj9HHbd71pBmgdhDHZ3qyTH2y6M9F687gS_JVZxRvDuCZU89Lg3UODFH9uII9m8NlB39sAcZMNYWQhiGJC_R8lUokyqsQFffsEvY6bFIoTpuxSK6U51X-ple3BFPNjGdFNTc0Jw5Qzwu8nrPdQ0x7Lf2KAruzrMT_fw5fTwuDdXgHeClyKOSfodvYRbKbsmSlcZgqX2WavSN78a_tO8Cds7DegM9JA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1039889429</pqid></control><display><type>article</type><title>Cytogenetic abnormalities in 222 infertile men with azoospermia and oligospermia in Iran: Report and review</title><source>PubMed Central Free</source><source>Portico Open Access Ejournals</source><source>Publicly Available Content (ProQuest)</source><creator>Akbari, Mohammad T ; Behjati, F ; Pourmand, G R ; Asbagh, F Akbari ; Kachoui, M Ataei</creator><creatorcontrib>Akbari, Mohammad T ; Behjati, F ; Pourmand, G R ; Asbagh, F Akbari ; Kachoui, M Ataei</creatorcontrib><description>Infertility affects approximately 10%-15% of couples in reproductive age. In half of the couples, causes are male-related, associated with impaired spermatogenesis. There is a complex correlation between genetics and infertility. Several factors affect on gametogenesis, from which factors that lead to chromosomal abnormalities are one of the best known. The aim of this study was to determine type and rate of chromosomal abnormalities in infertile azoospermic and oligospermic males in Iranian population. The records of a total of 222 participants were evaluated retrospectively. As a whole we observed 13.96% chromosomal abnormality, from which 12.15% showed numerical and 1.8% showed structural abnormalities. Comparison of our results with the review of the literature shows a higher incidence (4- fold) of gonosomal, in particular, numerical gonosomal, chromosomal anomalies. Cytogenetic analysis is strongly suggested for infertile men, particularly in those who suffer from azoospermia.</description><identifier>ISSN: 0971-6866</identifier><identifier>EISSN: 1998-362X</identifier><identifier>DOI: 10.4103/0971-6866.100764</identifier><identifier>PMID: 23162296</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Age ; Chromosome abnormalities ; Cytogenetics ; Gametogenesis ; Genetic aspects ; Infertility ; Infertility, Male ; Literature reviews ; Males ; Original ; Reviews ; Risk factors ; Sperm ; Spermatogenesis</subject><ispartof>Indian journal of human genetics, 2012-05, Vol.18 (2), p.198-203</ispartof><rights>COPYRIGHT 2012 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications &amp; Media Pvt Ltd 2012</rights><rights>Copyright: © Indian Journal of Human Genetics 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4774-ff4f6b2d4c5486b61abd896acc8a79d25d69fdb7479f3824285047e8877e17673</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491294/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1039889429?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23162296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Akbari, Mohammad T</creatorcontrib><creatorcontrib>Behjati, F</creatorcontrib><creatorcontrib>Pourmand, G R</creatorcontrib><creatorcontrib>Asbagh, F Akbari</creatorcontrib><creatorcontrib>Kachoui, M Ataei</creatorcontrib><title>Cytogenetic abnormalities in 222 infertile men with azoospermia and oligospermia in Iran: Report and review</title><title>Indian journal of human genetics</title><addtitle>Indian J Hum Genet</addtitle><description>Infertility affects approximately 10%-15% of couples in reproductive age. In half of the couples, causes are male-related, associated with impaired spermatogenesis. There is a complex correlation between genetics and infertility. Several factors affect on gametogenesis, from which factors that lead to chromosomal abnormalities are one of the best known. The aim of this study was to determine type and rate of chromosomal abnormalities in infertile azoospermic and oligospermic males in Iranian population. The records of a total of 222 participants were evaluated retrospectively. As a whole we observed 13.96% chromosomal abnormality, from which 12.15% showed numerical and 1.8% showed structural abnormalities. Comparison of our results with the review of the literature shows a higher incidence (4- fold) of gonosomal, in particular, numerical gonosomal, chromosomal anomalies. Cytogenetic analysis is strongly suggested for infertile men, particularly in those who suffer from azoospermia.</description><subject>Age</subject><subject>Chromosome abnormalities</subject><subject>Cytogenetics</subject><subject>Gametogenesis</subject><subject>Genetic aspects</subject><subject>Infertility</subject><subject>Infertility, Male</subject><subject>Literature reviews</subject><subject>Males</subject><subject>Original</subject><subject>Reviews</subject><subject>Risk factors</subject><subject>Sperm</subject><subject>Spermatogenesis</subject><issn>0971-6866</issn><issn>1998-362X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqFkt1rFDEUxYModtv67pMM-OLLrPnafPgglMVqoVAQC76FTObONnUmWZPZlvrXm-nW1ZYFyUMg93cuN-cehF4TPOcEs_dYS1ILJcScYCwFf4ZmRGtVM0G_P0ezXfkAHeZ8jTFllOuX6IAyIijVYoZ-LO_GuIIAo3eVbUJMg-396CFXPlSU0nJ1kEbfQzVAqG79eFXZXzHmNaTB28qGtoq9X-0eiuws2fCh-grrmMZ7IMGNh9tj9KKzfYZXD_cRujz99G35pT6_-Hy2PDmvHZeS113HO9HQlrsFV6IRxDat0sI6p6zULV20QndtI7nUHVOUU7XAXIJSUgKRQrIj9HHbd71pBmgdhDHZ3qyTH2y6M9F687gS_JVZxRvDuCZU89Lg3UODFH9uII9m8NlB39sAcZMNYWQhiGJC_R8lUokyqsQFffsEvY6bFIoTpuxSK6U51X-ple3BFPNjGdFNTc0Jw5Qzwu8nrPdQ0x7Lf2KAruzrMT_fw5fTwuDdXgHeClyKOSfodvYRbKbsmSlcZgqX2WavSN78a_tO8Cds7DegM9JA</recordid><startdate>201205</startdate><enddate>201205</enddate><creator>Akbari, Mohammad T</creator><creator>Behjati, F</creator><creator>Pourmand, G R</creator><creator>Asbagh, F Akbari</creator><creator>Kachoui, M Ataei</creator><general>Medknow Publications and Media Pvt. Ltd</general><general>Medknow Publications &amp; Media Pvt. Ltd</general><general>Medknow Publications &amp; Media Pvt Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88I</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PADUT</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201205</creationdate><title>Cytogenetic abnormalities in 222 infertile men with azoospermia and oligospermia in Iran: Report and review</title><author>Akbari, Mohammad T ; Behjati, F ; Pourmand, G R ; Asbagh, F Akbari ; Kachoui, M Ataei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4774-ff4f6b2d4c5486b61abd896acc8a79d25d69fdb7479f3824285047e8877e17673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Age</topic><topic>Chromosome abnormalities</topic><topic>Cytogenetics</topic><topic>Gametogenesis</topic><topic>Genetic aspects</topic><topic>Infertility</topic><topic>Infertility, Male</topic><topic>Literature reviews</topic><topic>Males</topic><topic>Original</topic><topic>Reviews</topic><topic>Risk factors</topic><topic>Sperm</topic><topic>Spermatogenesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Akbari, Mohammad T</creatorcontrib><creatorcontrib>Behjati, F</creatorcontrib><creatorcontrib>Pourmand, G R</creatorcontrib><creatorcontrib>Asbagh, F Akbari</creatorcontrib><creatorcontrib>Kachoui, M Ataei</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>ProQuest research library</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Research Library China</collection><collection>Publicly Available Content (ProQuest)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of human genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akbari, Mohammad T</au><au>Behjati, F</au><au>Pourmand, G R</au><au>Asbagh, F Akbari</au><au>Kachoui, M Ataei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytogenetic abnormalities in 222 infertile men with azoospermia and oligospermia in Iran: Report and review</atitle><jtitle>Indian journal of human genetics</jtitle><addtitle>Indian J Hum Genet</addtitle><date>2012-05</date><risdate>2012</risdate><volume>18</volume><issue>2</issue><spage>198</spage><epage>203</epage><pages>198-203</pages><issn>0971-6866</issn><eissn>1998-362X</eissn><abstract>Infertility affects approximately 10%-15% of couples in reproductive age. In half of the couples, causes are male-related, associated with impaired spermatogenesis. There is a complex correlation between genetics and infertility. Several factors affect on gametogenesis, from which factors that lead to chromosomal abnormalities are one of the best known. The aim of this study was to determine type and rate of chromosomal abnormalities in infertile azoospermic and oligospermic males in Iranian population. The records of a total of 222 participants were evaluated retrospectively. As a whole we observed 13.96% chromosomal abnormality, from which 12.15% showed numerical and 1.8% showed structural abnormalities. Comparison of our results with the review of the literature shows a higher incidence (4- fold) of gonosomal, in particular, numerical gonosomal, chromosomal anomalies. Cytogenetic analysis is strongly suggested for infertile men, particularly in those who suffer from azoospermia.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>23162296</pmid><doi>10.4103/0971-6866.100764</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0971-6866
ispartof Indian journal of human genetics, 2012-05, Vol.18 (2), p.198-203
issn 0971-6866
1998-362X
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3491294
source PubMed Central Free; Portico Open Access Ejournals; Publicly Available Content (ProQuest)
subjects Age
Chromosome abnormalities
Cytogenetics
Gametogenesis
Genetic aspects
Infertility
Infertility, Male
Literature reviews
Males
Original
Reviews
Risk factors
Sperm
Spermatogenesis
title Cytogenetic abnormalities in 222 infertile men with azoospermia and oligospermia in Iran: Report and review
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-24T17%3A44%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cytogenetic%20abnormalities%20in%20222%20infertile%20men%20with%20azoospermia%20and%20oligospermia%20in%20Iran:%20Report%20and%20review&rft.jtitle=Indian%20journal%20of%20human%20genetics&rft.au=Akbari,%20Mohammad%20T&rft.date=2012-05&rft.volume=18&rft.issue=2&rft.spage=198&rft.epage=203&rft.pages=198-203&rft.issn=0971-6866&rft.eissn=1998-362X&rft_id=info:doi/10.4103/0971-6866.100764&rft_dat=%3Cgale_pubme%3EA302431494%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c4774-ff4f6b2d4c5486b61abd896acc8a79d25d69fdb7479f3824285047e8877e17673%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1039889429&rft_id=info:pmid/23162296&rft_galeid=A302431494&rfr_iscdi=true