Bioinspired Controlled Release of CCL22 Recruits Regulatory T Cells In Vivo

A rationally designed controlled‐release system is developed to recruit suppressive immune cells to specific sites in vivo. Continuous and sustained release of the chemokine CCL22 is achieved by fabricating porous polymeric microspheres. Application of these porous particles in vivo, in mice, leads...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2012-09, Vol.24 (35), p.4735-4738
Main Authors: Jhunjhunwala, Siddharth, Raimondi, Giorgio, Glowacki, Andrew J., Hall, Sherri J., Maskarinec, Dan, Thorne, Stephen H., Thomson, Angus W., Little, Steven R.
Format: Article
Language:English
Subjects:
Animals
Biomimetics - methods
Cell Movement - drug effects
Cell Movement - immunology
chemokine
Chemokine CCL22 - administration & dosage
Chemokine CCL22 - metabolism
Chemokine CCL22 - pharmacology
Controlled release
Delayed-Action Preparations
Drug Carriers - chemistry
Female
Immune system
Immunomodulation - drug effects
Lymphocytes
Materials science
Mice
microparticles
Microspheres
polymeric materials
regulatory T cells
Sustained release
T-Lymphocytes, Regulatory - cytology
T-Lymphocytes, Regulatory - drug effects
T-Lymphocytes, Regulatory - immunology
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Summary:A rationally designed controlled‐release system is developed to recruit suppressive immune cells to specific sites in vivo. Continuous and sustained release of the chemokine CCL22 is achieved by fabricating porous polymeric microspheres. Application of these porous particles in vivo, in mice, leads to local regulatory T cell recruitment as well as a delay in rejection responses against transplanted allogeneic cells.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201202513