Diagnosis of bladder cancer by immunocytochemical detection of minichromosome maintenance protein-2 in cells retrieved from urine

Background: We tested the accuracy of immunocytochemistry (ICC) for minichromosome maintenance protein-2 (MCM-2) in diagnosing bladder cancer, using cells retrieved from urine. Methods: Adequate samples were obtained from 497 patients, the majority presenting with gross haematuria (GH) or undergoing...

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Bibliographic Details
Published in:British journal of cancer 2012-10, Vol.107 (8), p.1384-1391
Main Authors: Saeb-Parsy, K, Wilson, A, Scarpini, C, Corcoran, M, Chilcott, S, McKean, M, Thottakam, B, Rai, B, Nabi, G, Rana, D, Perera, M, Stewart, K, Laskey, R A, Neal, D E, Coleman, N
Format: Article
Language:English
Subjects:
631/1647/664/1569
692/699/67/1857
692/699/67/589/1336
692/700/139/1420/1919
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - urine
Biomedical and Life Sciences
Biomedicine
Bladder cancer
Cancer Research
Cell Cycle Proteins - urine
Cell Line, Tumor
Drug Resistance
Epidemiology
Female
Hematuria
Humans
Immunohistochemistry
Male
Medical sciences
Middle Aged
Minichromosome Maintenance Complex Component 2
Molecular Diagnostics
Molecular Medicine
Nephrology. Urinary tract diseases
Nuclear Proteins - urine
Oncology
ROC Curve
Tumors
Tumors of the urinary system
Urinary Bladder Neoplasms - diagnosis
Urinary Bladder Neoplasms - urine
Urinary tract. Prostate gland
Young Adult
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Summary:Background: We tested the accuracy of immunocytochemistry (ICC) for minichromosome maintenance protein-2 (MCM-2) in diagnosing bladder cancer, using cells retrieved from urine. Methods: Adequate samples were obtained from 497 patients, the majority presenting with gross haematuria (GH) or undergoing cystoscopic surveillance (CS) following previous bladder cancer. We performed an initial study of 313 patients, followed by a validation study of 184 patients. In all cases, presence/absence of bladder cancer was established by cystoscopy/biopsy. Results: In the initial study, receiver operator characteristic analysis showed an area under the curve of 0.820 ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.2012.381