Nickel-Mediated Oxidative Fluorination for PET with Aqueous [18F] Fluoride

A one-step oxidative fluorination for carbon–fluorine bond formation from well-defined nickel complexes with oxidant and aqueous fluoride is presented, which enables a straightforward and practical 18F late-stage fluorination of complex small molecules with potential for PET imaging.

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Bibliographic Details
Published in:Journal of the American Chemical Society 2012-10, Vol.134 (42), p.17456-17458
Main Authors: Lee, Eunsung, Hooker, Jacob M, Ritter, Tobias
Format: Article
Language:English
Subjects:
Fluorine - chemistry
Fluorine Radioisotopes
Molecular Structure
Nickel - chemistry
Organometallic Compounds - chemical synthesis
Organometallic Compounds - chemistry
Oxidation-Reduction
Positron-Emission Tomography
Water - chemistry
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Description
Summary:A one-step oxidative fluorination for carbon–fluorine bond formation from well-defined nickel complexes with oxidant and aqueous fluoride is presented, which enables a straightforward and practical 18F late-stage fluorination of complex small molecules with potential for PET imaging.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja3084797