Shape Matters: Intravital Microscopy Reveals Surprising Geometrical Dependence for Nanoparticles in Tumor Models of Extravasation

Delivery is one of the most critical obstacles confronting nanoparticle use in cancer diagnosis and therapy. For most oncological applications, nanoparticles must extravasate in order to reach tumor cells and perform their designated task. However, little understanding exists regarding the effect of...

Full description

Saved in:
Bibliographic Details
Published in:Nano letters 2012-07, Vol.12 (7), p.3369-3377
Main Authors: Smith, Bryan Ronain, Kempen, Paul, Bouley, Donna, Xu, Alexander, Liu, Zhuang, Melosh, Nicholas, Dai, Hongjie, Sinclair, Robert, Gambhir, Sanjiv Sam
Format: Article
Language:English
Subjects:
Animals
Charge
Coatings
Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science
rheology
Disease Models, Animal
Ear Neoplasms - blood supply
Ear Neoplasms - pathology
Exact sciences and technology
Humans
Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties
Materials science
Mice
Microscopy
Microscopy, Fluorescence
Nanocrystalline materials
Nanoparticles
Nanoparticles - chemistry
Nanoscale materials and structures: fabrication and characterization
Nanostructure
Nanotechnology
Nanotubes
Nanotubes, Carbon - chemistry
Neoplasms, Experimental - blood supply
Neoplasms, Experimental - pathology
Particle Size
Physics
Quantum Dots
Real time
Single wall carbon nanotubes
Surface Properties
Surfaces and interfaces
thin films and whiskers (structure and nonelectronic properties)
Tasks
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Delivery is one of the most critical obstacles confronting nanoparticle use in cancer diagnosis and therapy. For most oncological applications, nanoparticles must extravasate in order to reach tumor cells and perform their designated task. However, little understanding exists regarding the effect of nanoparticle shape on extravasation. Herein we use real-time intravital microscopic imaging to meticulously examine how two different nanoparticles behave across three different murine tumor models. The study quantitatively demonstrates that high-aspect ratio single-walled carbon nanotubes (SWNTs) display extravasational behavior surprisingly different from, and counterintuitive to, spherical nanoparticles although the nanoparticles have similar surface coatings, area, and charge. This work quantitatively indicates that nanoscale extravasational competence is highly dependent on nanoparticle geometry and is heterogeneous.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl204175t