Beyond biomarkers: Identifying cell state using unbiased nanosensor arrays

[Display omitted] ► Description of the unbiased array-based sensing method is presented. ► Selective interactions of sensors allow detection of subtle variations on cell surfaces. ► Unbiased array-based sensors have been used to discriminate cell states. Traditional cell detection based on biomarker...

Full description

Saved in:
Bibliographic Details
Published in:Nano today 2012-08, Vol.7 (4), p.228-230
Main Authors: Duncan, Bradley, Elci, S. Gokhan, Rotello, Vincent M.
Format: Article
Language:English
Subjects:
Biomarkers
Cancer cells
Nanoparticles
Unbiased sensors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:[Display omitted] ► Description of the unbiased array-based sensing method is presented. ► Selective interactions of sensors allow detection of subtle variations on cell surfaces. ► Unbiased array-based sensors have been used to discriminate cell states. Traditional cell detection based on biomarkers relies on specific lock-and-key recognition. However, many diseases either do not have obvious biomarkers or these markers are currently unknown. Unbiased sensor arrays based on nanoparticles use selective interactions to generate bioprofiles capable of identifying cell type and state. As a result, these arrays can differentiate subtle variations on the cell surfaces, presenting a potential approach for personalized diagnostics.
ISSN:1748-0132
1878-044X
DOI:10.1016/j.nantod.2012.06.001