Prognostic and predictive roles of KRAS mutation in colorectal cancer

The RAS gene family is among the most studied and best characterized of the known cancer-related genes. Of the three human ras isoforms, KRAS is the most frequently altered gene, with mutations occurring in 17%-25% of all cancers. In particular, approximately 30%-40% of colon cancers harbor a KRAS m...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2012-09, Vol.13 (10), p.12153-12168
Main Authors: Arrington, Amanda K, Heinrich, Eileen L, Lee, Wendy, Duldulao, Marjun, Patel, Supriya, Sanchez, Julian, Garcia-Aguilar, Julio, Kim, Joseph
Format: Article
Language:English
Subjects:
Colorectal cancer
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - genetics
Colorectal Neoplasms - metabolism
ErbB Receptors - genetics
ErbB Receptors - metabolism
Humans
MicroRNAs - metabolism
Polymorphism, Genetic
Prognosis
Proto-Oncogene Proteins B-raf - genetics
Proto-Oncogene Proteins B-raf - metabolism
ras Proteins - genetics
ras Proteins - metabolism
Review
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The RAS gene family is among the most studied and best characterized of the known cancer-related genes. Of the three human ras isoforms, KRAS is the most frequently altered gene, with mutations occurring in 17%-25% of all cancers. In particular, approximately 30%-40% of colon cancers harbor a KRAS mutation. KRAS mutations in colon cancers have been associated with poorer survival and increased tumor aggressiveness. Additionally, KRAS mutations in colorectal cancer lead to resistance to select treatment strategies. In this review we examine the history of KRAS, its prognostic value in patients with colorectal cancer, and evidence supporting its predictive value in determining appropriate therapies for patients with colorectal cancer.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms131012153