Molecular mechanisms of garlic-derived allyl sulfides in the inhibition of skin cancer progression

Skin cancer is a serious concern whose incidence is increasing at an alarming rate. Allyl sulfides—i.e., sulfur metabolites in garlic oil—have been demonstrated to have anticancer activity against several cancer types, although the mechanisms underlying these effects remain enigmatic. Our previous s...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2012-10, Vol.1271 (1), p.44-52
Main Authors: Wang, Hsiao-Chi, Pao, Jung, Lin, Shuw-Yuan, Sheen, Lee-Yan
Format: Article
Language:English
Subjects:
Allium sativum
Allyl Compounds - pharmacology
Allyl Compounds - therapeutic use
allyl sulfides
Animals
Anticarcinogenic Agents - pharmacology
Anticarcinogenic Agents - therapeutic use
Antineoplastic Agents, Phytogenic - pharmacology
Antineoplastic Agents, Phytogenic - therapeutic use
Apoptosis
Apoptosis - drug effects
Cancer
Damage
Disease Progression
DNA Damage - drug effects
Endoplasmic reticulum
Endoplasmic Reticulum Stress - drug effects
ER stress
G2 Phase - drug effects
Garlic
Garlic - chemistry
Humans
Melanoma - drug therapy
Melanoma - prevention & control
Melanoma - secondary
Metabolites
Original
Plant Oils - chemistry
Plant Roots - chemistry
Reactive Oxygen Species - antagonists & inhibitors
Reactive Oxygen Species - metabolism
ROS
Skin cancer
Skin Neoplasms - drug therapy
Skin Neoplasms - prevention & control
Sulfides
Sulfides - pharmacology
Sulfides - therapeutic use
Sulfur
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Summary:Skin cancer is a serious concern whose incidence is increasing at an alarming rate. Allyl sulfides—i.e., sulfur metabolites in garlic oil—have been demonstrated to have anticancer activity against several cancer types, although the mechanisms underlying these effects remain enigmatic. Our previous study showed that diallyl trisulfide (DATS) is more potent than mono‐ and disulfides against skin cancer. DATS inhibits cell growth of human melanoma A375 cells and basal cell carcinoma (BCC) cells by increasing the levels of intracellular reactive oxygen species (ROS) and DNA damage and by inducing G2/M arrest, endoplasmic reticulum (ER) stress, and mitochondria‐mediated apoptosis, including the caspase‐dependent and ‐independent pathways. This short review focuses on the molecular mechanisms of garlic‐derived allyl sulfides on skin cancer prevention.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2012.06743.x