Amphioxus makes the cut-Again

The cephalochordate amphioxus is now established as an important model system for understanding the evolution of vertebrate novelties from an invertebrate chordate ancestor. It is also emerging as a serious candidate for studies of organ regeneration. We extend here our previous observations on the...

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Bibliographic Details
Published in:Communicative & integrative biology 2012-09, Vol.5 (5), p.499-502
Main Authors: Somorjai, Ildikó M.L., Escrivà, Hector, Garcia-Fernàndez, Jordi
Format: Article
Language:English
Subjects:
Addendum
amphioxus
Binding
Biology
Bioscience
Branchiostoma lanceolatum
Calcium
Cancer
Cell
Cycle
Landes
Organogenesis
Proteins
repeated regeneration
Wnt
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Summary:The cephalochordate amphioxus is now established as an important model system for understanding the evolution of vertebrate novelties from an invertebrate chordate ancestor. It is also emerging as a serious candidate for studies of organ regeneration. We extend here our previous observations on the European amphioxus´ extensive adult regenerative capacity. The expression of Wnt5 and the presence of β-catenin protein in the early bud-stage blastema support a role for Wnt signaling during tail regeneration in amphioxus. We also present data showing that Branchiostoma lanceolatum continues to regenerate well after repeated amputation of the post-anal tail. These results are discussed in relation to vertebrate regeneration and other stem cell systems, and in the context of regeneration decline with aging.
ISSN:1942-0889
1942-0889
DOI:10.4161/cib.21075