Computational Modeling of Microabscess Formation

Bacterial infections can be of two types: acute or chronic. The chronic bacterial infections are characterized by being a large bacterial infection and/or an infection where the bacteria grows rapidly. In these cases, the immune response is not capable of completely eliminating the infection which m...

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Bibliographic Details
Published in:Computational and mathematical methods in medicine 2012-01, Vol.2012 (2012), p.1-16
Main Authors: Pigozzo, Alexandre Bittencourt, Macedo, Gilson Costa, dos Santos, Rodrigo Weber, Lobosco, Marcelo
Format: Article
Language:English
Subjects:
Abscess - microbiology
Abscess - physiopathology
Algorithms
Apoptosis
Bacterial Infections
Computer Simulation
Cytokines - metabolism
Humans
Immune System
Macrophages - immunology
Macrophages - microbiology
Models, Biological
Models, Theoretical
Neutrophils - immunology
Neutrophils - microbiology
Time Factors
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Summary:Bacterial infections can be of two types: acute or chronic. The chronic bacterial infections are characterized by being a large bacterial infection and/or an infection where the bacteria grows rapidly. In these cases, the immune response is not capable of completely eliminating the infection which may lead to the formation of a pattern known as microabscess (or abscess). The microabscess is characterized by an area comprising fluids, bacteria, immune cells (mainly neutrophils), and many types of dead cells. This distinct pattern of formation can only be numerically reproduced and studied by models that capture the spatiotemporal dynamics of the human immune system (HIS). In this context, our work aims to develop and implement an initial computational model to study the process of microabscess formation during a bacterial infection.
ISSN:1748-670X
1748-6718
DOI:10.1155/2012/736394