DNA Mismatch Repair System : Repercussions in Cellular Homeostasis and Relationship with Aging

The mechanisms that concern DNA repair have been studied in the last years due to their consequences in cellular homeostasis. The diverse and damaging stimuli that affect DNA integrity, such as changes in the genetic sequence and modifications in gene expression, can disrupt the steady state of the...

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Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2012-01, Vol.2012 (2012), p.1-9
Main Authors: Conde-Pérezprina, Juan Cristóbal, León-Galván, Miguel Ángel, Konigsberg, Mina
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Cell Cycle Checkpoints
DNA Mismatch Repair
DNA Repair Enzymes - metabolism
Homeostasis
Humans
Review
Telomere Shortening
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Summary:The mechanisms that concern DNA repair have been studied in the last years due to their consequences in cellular homeostasis. The diverse and damaging stimuli that affect DNA integrity, such as changes in the genetic sequence and modifications in gene expression, can disrupt the steady state of the cell and have serious repercussions to pathways that regulate apoptosis, senescence, and cancer. These altered pathways not only modify cellular and organism longevity, but quality of life (“health-span”). The DNA mismatch repair system (MMR) is highly conserved between species; its role is paramount in the preservation of DNA integrity, placing it as a necessary focal point in the study of pathways that prolong lifespan, aging, and disease. Here, we review different insights concerning the malfunction or absence of the DNA-MMR and its impact on cellular homeostasis. In particular, we will focus on DNA-MMR mechanisms regulated by known repair proteins MSH2, MSH6, PMS2, and MHL1, among others.
ISSN:1942-0900
1942-0994
DOI:10.1155/2012/728430