Diffuse Large B-Cell Lymphoma in Human T-Lymphotropic Virus Type 1 Carriers

We describe the clinical and pathological characteristics of seven patients who were human T-lymphotropic virus type 1 (HTLV-1) carriers and had a pathological diagnosis of de novo diffuse large B-cell lymphoma. Interestingly, three of our cases showed positive expression of Epstein-Barr-virus, (EBV...

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Bibliographic Details
Published in:Leukemia Research and Treatment 2012, Vol.2012 (2012), p.85-88
Main Authors: Morales, Domingo, Beltran, Brady E., Castillo, Jorge J., Alva, Jose C., Revilla, Jose C., Quiñones, Pilar
Format: Article
Language:English
Subjects:
Clinical Study
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Summary:We describe the clinical and pathological characteristics of seven patients who were human T-lymphotropic virus type 1 (HTLV-1) carriers and had a pathological diagnosis of de novo diffuse large B-cell lymphoma. Interestingly, three of our cases showed positive expression of Epstein-Barr-virus, (EBV-) encoded RNA within the tumor cells indicating a possible interaction between these two viruses. Furthermore, our three EBV-positive cases presented with similar clinical characteristics such as early clinical stage and low-risk indices. To the best of our knowledge, this is the first case series describing the characteristics of HTLV-1-positive DLBCL patients. The potential relationship between HTLV-1 and EBV should be further explored.
ISSN:2090-3219
2090-3227
DOI:10.1155/2012/262363