PET/MRI in head and neck cancer: initial experience

Purpose To evaluate the feasibility of PET/MRI (positron emission tomography/magnetic resonance imaging) with FDG ( 18 F-fluorodeoxyglucose) for initial staging of head and neck cancer. Methods The study group comprised 20 patients (16 men, 4 women) aged between 52 and 81 years (median 64 years) wit...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2013-01, Vol.40 (1), p.6-11
Main Authors: Platzek, Ivan, Beuthien-Baumann, Bettina, Schneider, Matthias, Gudziol, Volker, Langner, Jens, Schramm, Georg, Laniado, Michael, Kotzerke, Jörg, van den Hoff, Jörg
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - diagnostic imaging
Cardiology
Cerebellum
Feasibility studies
Female
Fluorodeoxyglucose F18 - administration & dosage
Head & neck cancer
Head and Neck Neoplasms - diagnosis
Head and Neck Neoplasms - diagnostic imaging
Humans
Imaging
Infusions, Intravenous
Lymph Nodes - diagnostic imaging
Lymph Nodes - pathology
Magnetic Resonance Imaging
Male
Medical prognosis
Medicine
Medicine & Public Health
Middle Aged
NMR
Nuclear magnetic resonance
Nuclear Medicine
Oncology
Original
Original Article
Orthopedics
Positron-Emission Tomography
Radiology
Radiopharmaceuticals - administration & dosage
Squamous Cell Carcinoma of Head and Neck
Tomography
Whole Body Imaging
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Summary:Purpose To evaluate the feasibility of PET/MRI (positron emission tomography/magnetic resonance imaging) with FDG ( 18 F-fluorodeoxyglucose) for initial staging of head and neck cancer. Methods The study group comprised 20 patients (16 men, 4 women) aged between 52 and 81 years (median 64 years) with histologically proven squamous cell carcinoma of the head and neck region. The patients underwent a PET scan on a conventional scanner and a subsequent PET/MRI examination on a whole-body hybrid system. FDG was administered intravenously prior to the conventional PET scan (267–395 MBq FDG, 348 MBq on average). The maximum standardized uptake values (SUV max ) of the tumour and of both cerebellar hemispheres were determined for both PET datasets. The numbers of lymph nodes with increased FDG uptake were compared between the two PET datasets. Results No MRI-induced artefacts where observed in the PET images. The tumour was detected by PET/MRI in 17 of the 20 patients, by PET in 16 and by MRI in 14. The PET/MRI examination yielded significantly higher SUV max than the conventional PET scanner for both the tumour ( p  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-012-2248-z