Shared biological risks that influence brain and behaviour

The evidence suggests there is contribution from both common genetic variants of small effect size and rare variants (copy number variants) of larger effect size. 1 Such variants have been found to impact on similar biological pathways, interestingly including one related to nicotinic acetylcholine...

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Bibliographic Details
Published in:Archives of disease in childhood 2012-12, Vol.97 (12), p.1011-1012
Main Authors: Cooper, Miriam, Thapar, Anita
Format: Article
Language:English
Subjects:
Academic Achievement
Attention Deficit Disorder with Hyperactivity - genetics
Attention deficit hyperactivity disorder
Autism
Behavior disorders
Causes of
Child Psychiatry
Comorbidity
Diagnostic Teaching
Effect Size
Evidence
Genes
Genetic aspects
Genetic variance
Genetics
Genomes
Health Behavior
Humans
Hypotheses
Learning Problems
Mental Disorders
Meta Analysis
Neurosciences
Polymorphism, Single Nucleotide
Pregnancy
Psychiatry
Psychopathology
Risk factors
Sample Size
Smoking
Smoking - genetics
Studies
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Description
Summary:The evidence suggests there is contribution from both common genetic variants of small effect size and rare variants (copy number variants) of larger effect size. 1 Such variants have been found to impact on similar biological pathways, interestingly including one related to nicotinic acetylcholine receptor signalling. 2 3 There is also growing evidence that ADHD inherited risks and associated gene variants have different phenotypic effects (pleiotropy).
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2012-302461