Development and evaluation of a thermosensitive vaginal gel containing raltegravir+efavirenz loaded nanoparticles for HIV prophylaxis

• Published in: Antiviral research 2012-12, Vol.96 (3), p.430-436
• Main Authors: Date, Abhijit A., Shibata, Annemarie, Goede, Michael, Sanford, Bridget, La Bruzzo, Krista, Belshan, Michel, Destache, Christopher J.
• Format: Article
• Language: English
• Subjects: Alkynes; Anti-HIV Agents - chemistry; Anti-HIV Agents - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Benzoxazines - chemistry; Benzoxazines - pharmacology; Biological and medical sciences; Chromatography, High Pressure Liquid; Cyclopropanes; Cytotoxicity; Data processing; Disease transmission; Drug Carriers - administration & dosage; Drug Carriers - chemistry; Drug Evaluation, Preclinical; Efavirenz; Encapsulation; Evaporation; Gels; Gels - chemistry; Gels - pharmacology; HeLa Cells; HIV; HIV Infections - prevention & control; HIV Infections - virology; HIV-1 - drug effects; Human immunodeficiency virus 1; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Intracellular levels; Lactic Acid - chemistry; Medical sciences; Microbial Sensitivity Tests; Nanoparticles; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Phagocytosis; Pharmacology. Drug treatments; Poloxamer - chemistry; Polyglycolic Acid - chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; polylactide-co-glycolide; Pre-exposure prophylaxis; Prophylaxis; Pyrrolidinones - chemistry; Pyrrolidinones - pharmacology; Raltegravir; Raltegravir Potassium; Surface charge; Temperature; Thermosensitive gel; Time Factors; Vagina; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Zeta potential
• ISSN: 0166-3542; 1872-9096
• DOI: 10.1016/j.antiviral.2012.09.015

► The PLGA nanoparticles (NPs) are