Cholesterol and prostate cancer

Graphical abstract Highlights ► Hypercholesterolemia increases the risk of aggressive prostate cancer. ► Cholesterol-lowering statin drugs reduce the risk of aggressive prostate cancer. ► Hypercholesterolemia may elicit multiple mechanisms that affect prostate cancer. ► Hypercholesterolemia may be a...

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Bibliographic Details
Published in:Current opinion in pharmacology 2012-12, Vol.12 (6), p.751-759
Main Authors: Pelton, Kristine, Freeman, Michael R, Solomon, Keith R
Format: Article
Language:English
Subjects:
Animals
Anticholesteremic Agents - therapeutic use
Cholesterol - metabolism
Disease Models, Animal
Humans
Hypercholesterolemia - complications
Hypercholesterolemia - drug therapy
Internal Medicine
Male
Medical Education
Models, Biological
Prostatic Neoplasms - etiology
Prostatic Neoplasms - pathology
Prostatic Neoplasms - prevention & control
Risk Factors
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Summary:Graphical abstract Highlights ► Hypercholesterolemia increases the risk of aggressive prostate cancer. ► Cholesterol-lowering statin drugs reduce the risk of aggressive prostate cancer. ► Hypercholesterolemia may elicit multiple mechanisms that affect prostate cancer. ► Hypercholesterolemia may be a risk factor for developing castration-resistance.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2012.07.006