Occurrence of Paracoccidioides lutzii in the Amazon region: description of two cases

Paracoccidioidomycosis (PCM), the most important human systemic mycosis in Latin America, is known to be caused by at least four different phylogenetic lineages within the Paracoccidioides brasiliensis complex, including S1, PS2, PS3, and Pb01-like group. Herein, we describe two cases of PCM in pati...

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Bibliographic Details
Published in:The American journal of tropical medicine and hygiene 2012-10, Vol.87 (4), p.710-714
Main Authors: Marques-da-Silva, Silvia Helena, Rodrigues, Anderson Messias, de Hoog, G Sybren, Silveira-Gomes, Fabíola, Camargo, Zoilo Pires de
Format: Article
Language:English
Subjects:
ADP-Ribosylation Factor 1 - genetics
Adult
Antigens, Fungal - genetics
Brazil - epidemiology
DNA, Fungal - analysis
DNA, Fungal - isolation & purification
Female
Fungal Proteins - genetics
Glycoproteins - genetics
Humans
Male
Middle Aged
Molecular Sequence Data
Paracoccidioides
Paracoccidioides - classification
Paracoccidioides - genetics
Paracoccidioides - isolation & purification
Paracoccidioides brasiliensis
Paracoccidioidomycosis - epidemiology
Paracoccidioidomycosis - microbiology
Phylogeny
Sequence Analysis, DNA
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Summary:Paracoccidioidomycosis (PCM), the most important human systemic mycosis in Latin America, is known to be caused by at least four different phylogenetic lineages within the Paracoccidioides brasiliensis complex, including S1, PS2, PS3, and Pb01-like group. Herein, we describe two cases of PCM in patients native from the Amazon region. The disease was originally thought to have been caused by P. brasiliensis. Despite the severity of the cases, sera from the patients were negative in immunodiffusion tests using the standard exoantigen from P. brasiliensis B-339. However, a positive response was recorded with an autologous preparation of Paracoccidioides lutzii exoantigen. A phylogenetic approach based on the gp43 and ARF loci revealed high similarity between our clinical isolates and the Pb01-like group. The occurrence of PCM caused by P. lutzii in the Brazilian Amazon (Pará State) was thus proven. The incidence of PCM caused by P. lutzii may be underestimated in northern Brazil.
ISSN:0002-9637
1476-1645
DOI:10.4269/ajtmh.2012.12-0340