Daytime REM sleep in Parkinson's disease

Abstract Background Previous studies have demonstrated both clinical and neurochemical similarities between Parkinson's disease (PD) and narcolepsy. The intrusion of REM sleep into the daytime remains a cardinal feature of narcolepsy, but the importance of these intrusions in PD remains unclear...

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Bibliographic Details
Published in:Parkinsonism & related disorders 2013-01, Vol.19 (1), p.101-103
Main Authors: Bliwise, Donald L, Trotti, Lynn Marie, Juncos, Jorge J, Factor, Stewart A, Freeman, Alan, Rye, David B
Format: Article
Language:English
Subjects:
Aged
Female
Humans
Male
Middle Aged
Narcolepsy
Narcolepsy - physiopathology
Neurology
Parkinson Disease - physiopathology
Parkinson's disease
REM sleep
Sleep Stages - physiology
Sleep, REM - physiology
Wakefulness - physiology
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Summary:Abstract Background Previous studies have demonstrated both clinical and neurochemical similarities between Parkinson's disease (PD) and narcolepsy. The intrusion of REM sleep into the daytime remains a cardinal feature of narcolepsy, but the importance of these intrusions in PD remains unclear. In this study we examined REM sleep during daytime Maintenance of Wakefulness Testing (MWT) in PD patients. Methods Patients spent 2 consecutive nights and days in the sleep laboratory. During the daytime, we employed a modified MWT procedure in which each daytime nap opportunity (4 per day) was extended to 40 min, regardless of whether the patient was able to sleep or how much the patient slept. We examined each nap opportunity for the presence of REM sleep and time to fall asleep. Results Eleven of 63 PD patients studied showed 2 or more REM episodes and 10 showed 1 REM episode on their daytime MWTs. Nocturnal sleep characteristics and sleep disorders were unrelated to the presence of daytime REM sleep, however, patients with daytime REM were significantly sleepier during the daytime than those patients without REM. Demographic and clinical variables, including Unified Parkinson's Disease Rating Scale motor scores and levodopa dose equivalents, were unrelated to the presence of REM sleep. Conclusions A sizeable proportion of PD patients demonstrated REM sleep and daytime sleep tendency during daytime nap testing. These data confirm similarities in REM intrusions between narcolepsy and PD, perhaps suggesting parallel neurodegenerative conditions of hypocretin deficiency.
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2012.08.003