Loading…
Adipocyte Deficiency of Angiotensinogen Prevents Obesity-Induced Hypertension in Male Mice
Previous studies demonstrated that diet-induced obesity increased plasma angiotensin II concentrations and elevated systolic blood pressures in male mice. Adipocytes express angiotensinogen and secrete angiotensin peptides. We hypothesize that adipocyte-derived angiotensin II mediates obesity-induce...
Saved in:
| Published in: | Hypertension (Dallas, Tex. 1979) Tex. 1979), 2012-12, Vol.60 (6), p.1524-1530 |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c6340-33a136d294a9efde33b37faa2919408b69dcf287b233d6c724311208e0bafe9c3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c6340-33a136d294a9efde33b37faa2919408b69dcf287b233d6c724311208e0bafe9c3 |
| container_end_page | 1530 |
| container_issue | 6 |
| container_start_page | 1524 |
| container_title | Hypertension (Dallas, Tex. 1979) |
| container_volume | 60 |
| creator | Yiannikouris, Frederique Gupte, Manisha Putnam, Kelly Thatcher, Sean Charnigo, Richard Rateri, Debra L Daugherty, Alan Cassis, Lisa A |
| description | Previous studies demonstrated that diet-induced obesity increased plasma angiotensin II concentrations and elevated systolic blood pressures in male mice. Adipocytes express angiotensinogen and secrete angiotensin peptides. We hypothesize that adipocyte-derived angiotensin II mediates obesity-induced increases in systolic blood pressure in male high fat-fed C57BL/6 mice. Systolic blood pressure was measured by radiotelemetry during week 16 of low-fat or high-fat feeding in Agt and adipocyte angiotensinogen-deficient mice (Agt). Adipocyte angiotensinogen deficiency had no effect on diet-induced obesity. Basal 24-hour systolic blood pressure was not different in low fat-fed Agt compared with Agt mice (124±3 versus 128±3 mm Hg, respectively). In Agt mice, high-fat feeding significantly increased systolic blood pressure (24 hours; 134±2 mm Hg; P |
| doi_str_mv | 10.1161/HYPERTENSIONAHA.112.192690 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3517298</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1171865788</sourcerecordid><originalsourceid>FETCH-LOGICAL-c6340-33a136d294a9efde33b37faa2919408b69dcf287b233d6c724311208e0bafe9c3</originalsourceid><addsrcrecordid>eNqNkU9v1DAQxS0EotvCV0ARElIvKf63dswBKSpbdqW2W0GRgIvlOJNdQ9Ze7KRVvj0pu7TAidNIM79580YPoZcEnxAiyOv5l6vZh-vZ5cfF8rKcl2OTnhBFhcKP0IRMKc_5VLDHaIKJ4rki5PMBOkzpG8aEcy6fogPKCC4ElxP0tazdNtihg-wdNM468HbIQpOVfuVCBz45H1bgs6sIN-C7lC0rSK4b8oWvewt1Nh-2EH-BwWfOZxemhezCWXiGnjSmTfB8X4_Qp7PZ9ek8P1--X5yW57kVjOOcMUOYqKniRkFTA2MVk40xVI3ucVEJVduGFrKijNXCSsrZ-DAuAFemAWXZEXq709321QZqO7qMptXb6DYmDjoYp_-eeLfWq3Cj2ZRIqopR4HgvEMOPHlKnNy5ZaFvjIfRJEyJJIaayuEPf7FAbQ0oRmvszBOu7cPQ_4YxNqnfhjMsv_jR6v_o7jRF4tQdMsqZtovHWpQdOCIqxxA8f34a2g5i-t_0tRL0G03br_3HyE05Nr5E</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1171865788</pqid></control><display><type>article</type><title>Adipocyte Deficiency of Angiotensinogen Prevents Obesity-Induced Hypertension in Male Mice</title><source>EZB Free E-Journals</source><creator>Yiannikouris, Frederique ; Gupte, Manisha ; Putnam, Kelly ; Thatcher, Sean ; Charnigo, Richard ; Rateri, Debra L ; Daugherty, Alan ; Cassis, Lisa A</creator><creatorcontrib>Yiannikouris, Frederique ; Gupte, Manisha ; Putnam, Kelly ; Thatcher, Sean ; Charnigo, Richard ; Rateri, Debra L ; Daugherty, Alan ; Cassis, Lisa A</creatorcontrib><description>Previous studies demonstrated that diet-induced obesity increased plasma angiotensin II concentrations and elevated systolic blood pressures in male mice. Adipocytes express angiotensinogen and secrete angiotensin peptides. We hypothesize that adipocyte-derived angiotensin II mediates obesity-induced increases in systolic blood pressure in male high fat-fed C57BL/6 mice. Systolic blood pressure was measured by radiotelemetry during week 16 of low-fat or high-fat feeding in Agt and adipocyte angiotensinogen-deficient mice (Agt). Adipocyte angiotensinogen deficiency had no effect on diet-induced obesity. Basal 24-hour systolic blood pressure was not different in low fat-fed Agt compared with Agt mice (124±3 versus 128±3 mm Hg, respectively). In Agt mice, high-fat feeding significantly increased systolic blood pressure (24 hours; 134±2 mm Hg; P<0.05). In contrast, high fat-fed Agt mice did not exhibit an increase in systolic blood pressure (126±2 mm Hg). Plasma angiotensin II concentrations were increased by high-fat feeding in Agt mice (low fat, 32±14; high fat, 219±58 pg/mL; P<0.05). In contrast, high fat-fed Agt mice did not exhibit elevated plasma angiotensin II concentrations (high fat, 18±7 pg/mL). Similarly, adipose tissue concentrations of angiotensin II were significantly decreased in low fat- and high fat-fed Agt mice compared with controls. In conclusion, adipocyte angiotensinogen deficiency prevented high fat-induced elevations in plasma angiotensin II concentrations and systolic blood pressure. These results suggest that adipose tissue serves as a major source of angiotensin II in the development of obesity hypertension.</description><identifier>ISSN: 0194-911X</identifier><identifier>EISSN: 1524-4563</identifier><identifier>DOI: 10.1161/HYPERTENSIONAHA.112.192690</identifier><identifier>PMID: 23108647</identifier><identifier>CODEN: HPRTDN</identifier><language>eng</language><publisher>Hagerstown, MD: American Heart Association, Inc</publisher><subject>Adipocytes - metabolism ; Adipose Tissue - metabolism ; Angiotensinogen - genetics ; Angiotensinogen - metabolism ; Animals ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure - physiology ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Diet ; Heart Rate - physiology ; Hypertension - etiology ; Hypertension - genetics ; Hypertension - metabolism ; Male ; Medical sciences ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Obesity - complications ; Obesity - genetics ; Obesity - metabolism</subject><ispartof>Hypertension (Dallas, Tex. 1979), 2012-12, Vol.60 (6), p.1524-1530</ispartof><rights>2012 American Heart Association, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6340-33a136d294a9efde33b37faa2919408b69dcf287b233d6c724311208e0bafe9c3</citedby><cites>FETCH-LOGICAL-c6340-33a136d294a9efde33b37faa2919408b69dcf287b233d6c724311208e0bafe9c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26620070$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23108647$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yiannikouris, Frederique</creatorcontrib><creatorcontrib>Gupte, Manisha</creatorcontrib><creatorcontrib>Putnam, Kelly</creatorcontrib><creatorcontrib>Thatcher, Sean</creatorcontrib><creatorcontrib>Charnigo, Richard</creatorcontrib><creatorcontrib>Rateri, Debra L</creatorcontrib><creatorcontrib>Daugherty, Alan</creatorcontrib><creatorcontrib>Cassis, Lisa A</creatorcontrib><title>Adipocyte Deficiency of Angiotensinogen Prevents Obesity-Induced Hypertension in Male Mice</title><title>Hypertension (Dallas, Tex. 1979)</title><addtitle>Hypertension</addtitle><description>Previous studies demonstrated that diet-induced obesity increased plasma angiotensin II concentrations and elevated systolic blood pressures in male mice. Adipocytes express angiotensinogen and secrete angiotensin peptides. We hypothesize that adipocyte-derived angiotensin II mediates obesity-induced increases in systolic blood pressure in male high fat-fed C57BL/6 mice. Systolic blood pressure was measured by radiotelemetry during week 16 of low-fat or high-fat feeding in Agt and adipocyte angiotensinogen-deficient mice (Agt). Adipocyte angiotensinogen deficiency had no effect on diet-induced obesity. Basal 24-hour systolic blood pressure was not different in low fat-fed Agt compared with Agt mice (124±3 versus 128±3 mm Hg, respectively). In Agt mice, high-fat feeding significantly increased systolic blood pressure (24 hours; 134±2 mm Hg; P<0.05). In contrast, high fat-fed Agt mice did not exhibit an increase in systolic blood pressure (126±2 mm Hg). Plasma angiotensin II concentrations were increased by high-fat feeding in Agt mice (low fat, 32±14; high fat, 219±58 pg/mL; P<0.05). In contrast, high fat-fed Agt mice did not exhibit elevated plasma angiotensin II concentrations (high fat, 18±7 pg/mL). Similarly, adipose tissue concentrations of angiotensin II were significantly decreased in low fat- and high fat-fed Agt mice compared with controls. In conclusion, adipocyte angiotensinogen deficiency prevented high fat-induced elevations in plasma angiotensin II concentrations and systolic blood pressure. These results suggest that adipose tissue serves as a major source of angiotensin II in the development of obesity hypertension.</description><subject>Adipocytes - metabolism</subject><subject>Adipose Tissue - metabolism</subject><subject>Angiotensinogen - genetics</subject><subject>Angiotensinogen - metabolism</subject><subject>Animals</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Blood Pressure - physiology</subject><subject>Cardiology. Vascular system</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Diet</subject><subject>Heart Rate - physiology</subject><subject>Hypertension - etiology</subject><subject>Hypertension - genetics</subject><subject>Hypertension - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Obesity - complications</subject><subject>Obesity - genetics</subject><subject>Obesity - metabolism</subject><issn>0194-911X</issn><issn>1524-4563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNkU9v1DAQxS0EotvCV0ARElIvKf63dswBKSpbdqW2W0GRgIvlOJNdQ9Ze7KRVvj0pu7TAidNIM79580YPoZcEnxAiyOv5l6vZh-vZ5cfF8rKcl2OTnhBFhcKP0IRMKc_5VLDHaIKJ4rki5PMBOkzpG8aEcy6fogPKCC4ElxP0tazdNtihg-wdNM468HbIQpOVfuVCBz45H1bgs6sIN-C7lC0rSK4b8oWvewt1Nh-2EH-BwWfOZxemhezCWXiGnjSmTfB8X4_Qp7PZ9ek8P1--X5yW57kVjOOcMUOYqKniRkFTA2MVk40xVI3ucVEJVduGFrKijNXCSsrZ-DAuAFemAWXZEXq709321QZqO7qMptXb6DYmDjoYp_-eeLfWq3Cj2ZRIqopR4HgvEMOPHlKnNy5ZaFvjIfRJEyJJIaayuEPf7FAbQ0oRmvszBOu7cPQ_4YxNqnfhjMsv_jR6v_o7jRF4tQdMsqZtovHWpQdOCIqxxA8f34a2g5i-t_0tRL0G03br_3HyE05Nr5E</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Yiannikouris, Frederique</creator><creator>Gupte, Manisha</creator><creator>Putnam, Kelly</creator><creator>Thatcher, Sean</creator><creator>Charnigo, Richard</creator><creator>Rateri, Debra L</creator><creator>Daugherty, Alan</creator><creator>Cassis, Lisa A</creator><general>American Heart Association, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201212</creationdate><title>Adipocyte Deficiency of Angiotensinogen Prevents Obesity-Induced Hypertension in Male Mice</title><author>Yiannikouris, Frederique ; Gupte, Manisha ; Putnam, Kelly ; Thatcher, Sean ; Charnigo, Richard ; Rateri, Debra L ; Daugherty, Alan ; Cassis, Lisa A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6340-33a136d294a9efde33b37faa2919408b69dcf287b233d6c724311208e0bafe9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adipocytes - metabolism</topic><topic>Adipose Tissue - metabolism</topic><topic>Angiotensinogen - genetics</topic><topic>Angiotensinogen - metabolism</topic><topic>Animals</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Blood Pressure - physiology</topic><topic>Cardiology. Vascular system</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Diet</topic><topic>Heart Rate - physiology</topic><topic>Hypertension - etiology</topic><topic>Hypertension - genetics</topic><topic>Hypertension - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>Obesity - complications</topic><topic>Obesity - genetics</topic><topic>Obesity - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yiannikouris, Frederique</creatorcontrib><creatorcontrib>Gupte, Manisha</creatorcontrib><creatorcontrib>Putnam, Kelly</creatorcontrib><creatorcontrib>Thatcher, Sean</creatorcontrib><creatorcontrib>Charnigo, Richard</creatorcontrib><creatorcontrib>Rateri, Debra L</creatorcontrib><creatorcontrib>Daugherty, Alan</creatorcontrib><creatorcontrib>Cassis, Lisa A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yiannikouris, Frederique</au><au>Gupte, Manisha</au><au>Putnam, Kelly</au><au>Thatcher, Sean</au><au>Charnigo, Richard</au><au>Rateri, Debra L</au><au>Daugherty, Alan</au><au>Cassis, Lisa A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adipocyte Deficiency of Angiotensinogen Prevents Obesity-Induced Hypertension in Male Mice</atitle><jtitle>Hypertension (Dallas, Tex. 1979)</jtitle><addtitle>Hypertension</addtitle><date>2012-12</date><risdate>2012</risdate><volume>60</volume><issue>6</issue><spage>1524</spage><epage>1530</epage><pages>1524-1530</pages><issn>0194-911X</issn><eissn>1524-4563</eissn><coden>HPRTDN</coden><abstract>Previous studies demonstrated that diet-induced obesity increased plasma angiotensin II concentrations and elevated systolic blood pressures in male mice. Adipocytes express angiotensinogen and secrete angiotensin peptides. We hypothesize that adipocyte-derived angiotensin II mediates obesity-induced increases in systolic blood pressure in male high fat-fed C57BL/6 mice. Systolic blood pressure was measured by radiotelemetry during week 16 of low-fat or high-fat feeding in Agt and adipocyte angiotensinogen-deficient mice (Agt). Adipocyte angiotensinogen deficiency had no effect on diet-induced obesity. Basal 24-hour systolic blood pressure was not different in low fat-fed Agt compared with Agt mice (124±3 versus 128±3 mm Hg, respectively). In Agt mice, high-fat feeding significantly increased systolic blood pressure (24 hours; 134±2 mm Hg; P<0.05). In contrast, high fat-fed Agt mice did not exhibit an increase in systolic blood pressure (126±2 mm Hg). Plasma angiotensin II concentrations were increased by high-fat feeding in Agt mice (low fat, 32±14; high fat, 219±58 pg/mL; P<0.05). In contrast, high fat-fed Agt mice did not exhibit elevated plasma angiotensin II concentrations (high fat, 18±7 pg/mL). Similarly, adipose tissue concentrations of angiotensin II were significantly decreased in low fat- and high fat-fed Agt mice compared with controls. In conclusion, adipocyte angiotensinogen deficiency prevented high fat-induced elevations in plasma angiotensin II concentrations and systolic blood pressure. These results suggest that adipose tissue serves as a major source of angiotensin II in the development of obesity hypertension.</abstract><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>23108647</pmid><doi>10.1161/HYPERTENSIONAHA.112.192690</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0194-911X |
| ispartof | Hypertension (Dallas, Tex. 1979), 2012-12, Vol.60 (6), p.1524-1530 |
| issn | 0194-911X 1524-4563 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3517298 |
| source | EZB Free E-Journals |
| subjects | Adipocytes - metabolism Adipose Tissue - metabolism Angiotensinogen - genetics Angiotensinogen - metabolism Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - physiology Cardiology. Vascular system Clinical manifestations. Epidemiology. Investigative techniques. Etiology Diet Heart Rate - physiology Hypertension - etiology Hypertension - genetics Hypertension - metabolism Male Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Obesity - complications Obesity - genetics Obesity - metabolism |
| title | Adipocyte Deficiency of Angiotensinogen Prevents Obesity-Induced Hypertension in Male Mice |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T22%3A59%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Adipocyte%20Deficiency%20of%20Angiotensinogen%20Prevents%20Obesity-Induced%20Hypertension%20in%20Male%20Mice&rft.jtitle=Hypertension%20(Dallas,%20Tex.%201979)&rft.au=Yiannikouris,%20Frederique&rft.date=2012-12&rft.volume=60&rft.issue=6&rft.spage=1524&rft.epage=1530&rft.pages=1524-1530&rft.issn=0194-911X&rft.eissn=1524-4563&rft.coden=HPRTDN&rft_id=info:doi/10.1161/HYPERTENSIONAHA.112.192690&rft_dat=%3Cproquest_pubme%3E1171865788%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c6340-33a136d294a9efde33b37faa2919408b69dcf287b233d6c724311208e0bafe9c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1171865788&rft_id=info:pmid/23108647&rfr_iscdi=true |