Surface chemistry-mediated penetration and gold nanorod thermotherapy in multicellular tumor spheroids

We investigated the penetration and thermotherapy efficiency of different surface coated gold nanorods (Au NRs) in multicellular tumor spheroids. The current data show that negatively charged Au NRs, other than positively charged Au NRs, can penetrate deep into the tumor spheroids and achieve a sign...

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Bibliographic Details
Published in:Nanoscale 2013-01, Vol.5 (1), p.143-146
Main Authors: Jin, Shubin, Ma, Xiaowei, Ma, Huili, Zheng, Kaiyuan, Liu, Juan, Hou, Shuai, Meng, Jie, Wang, Paul C, Wu, Xiaochun, Liang, Xing-Jie
Format: Article
Language:English
Subjects:
Charging
Diffusion
Gold
Gold - therapeutic use
Humans
Hyperthermia, Induced - methods
Materials Testing
MCF-7 Cells
Metal Nanoparticles - administration & dosage
Metal Nanoparticles - chemistry
Metal Nanoparticles - ultrastructure
Nanocomposites
Nanomaterials
Nanostructure
Particle Size
Penetration
Spheroids
Spheroids, Cellular - chemistry
Spheroids, Cellular - drug effects
Static Electricity
Surface Properties
Treatment Outcome
Tumors
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Summary:We investigated the penetration and thermotherapy efficiency of different surface coated gold nanorods (Au NRs) in multicellular tumor spheroids. The current data show that negatively charged Au NRs, other than positively charged Au NRs, can penetrate deep into the tumor spheroids and achieve a significant thermal therapeutic benefit.
ISSN:2040-3364
2040-3372
DOI:10.1039/c2nr31877f